Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

por Huiting, Wouter, Dekker, Suzanne L, van der Lienden, Joris CJ, Mergener, Rafaella, Musskopf, Maiara K, Furtado, Gabriel V, Gerrits, Emma, Coit, David, Oghbaie, Mehrnoosh, Di Stefano, Luciano H, Schepers, Hein, van Waarde-Verhagen, Maria AWH, Couzijn, Suzanne, Barazzuol, Lara, LaCava, John, Kampinga, Harm H, Bergink, Steven
Publicado 2022

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

por Meister-Broekema, Melanie, Freilich, Rebecca, Jagadeesan, Chandhuru, Rauch, Jennifer N., Bengoechea, Rocio, Motley, William W., Kuiper, E. F. Elsiena, Minoia, Melania, Furtado, Gabriel V., van Waarde, Maria A. W. H., Bird, Shawn J., Rebelo, Adriana, Zuchner, Stephan, Pytel, Peter, Scherer, Steven S., Morelli, Federica F., Carra, Serena, Weihl, Conrad C., Bergink, Steven, Gestwicki, Jason E., Kampinga, Harm H.
Publicado 2018