IL-17F induces inflammation, dysfunction and cell death in mouse islets

por Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E., Sutherland, Andrew P. R.
Publicado 2020

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

por Wali, Jibran A., Gurzov, Esteban N., Fynch, Stacey, Elkerbout, Lorraine, Kay, Thomas W., Masters, Seth L., Thomas, Helen E.
Publicado 2014

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

por Sachithanandan, Nirupa, Graham, Kate L., Galic, Sandra, Honeyman, Jane E., Fynch, Stacey L., Hewitt, Kimberly A., Steinberg, Gregory R., Kay, Thomas W.
Publicado 2011

IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

por Sutherland, Andrew P. R., Graham, Kate L., Papadimitriou, Michelle, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E.
Publicado 2019

Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

por Carrington, Emma M., McKenzie, Mark D., Jansen, Elisa, Myers, Michelle, Fynch, Stacey, Kos, Cameron, Strasser, Andreas, Kay, Thomas W., Scott, Clare L., Allison, Janette
Publicado 2009

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

por Trivedi, Prerak M., Fynch, Stacey, Kennedy, Lucy M., Chee, Jonathan, Krishnamurthy, Balasubramanian, O’Reilly, Lorraine A., Strasser, Andreas, Kay, Thomas W. H., Thomas, Helen E.
Publicado 2019

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

por Krishnamurthy, Balasubramanian, Chee, Jonathan, Jhala, Gaurang, Fynch, Stacey, Graham, Kate L., Santamaria, Pere, Morahan, Grant, Allison, Janette, Izon, David, Thomas, Helen E., Kay, Thomas W.H.
Publicado 2012

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

por Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E
Publicado 2014

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

por Ge, Tingting, Jhala, Gaurang, Fynch, Stacey, Akazawa, Satoru, Litwak, Sara, Pappas, Evan G., Catterall, Tara, Vakil, Ishan, Long, Andrew J., Olson, Lisa M., Krishnamurthy, Balasubramanian, Kay, Thomas W., Thomas, Helen E.
Publicado 2020

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice

por Chia, Joanne S.J., McRae, Jennifer L., Thomas, Helen E., Fynch, Stacey, Elkerbout, Lorraine, Hill, Prue, Murray-Segal, Lisa, Robson, Simon C., Chen, Jiang-Fan, d’Apice, Anthony J.F., Cowan, Peter J., Dwyer, Karen M.
Publicado 2013

Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor

por Ge, Tingting, Phung, Amber‐Lee, Jhala, Gaurang, Trivedi, Prerak, Principe, Nicola, De George, David J, Pappas, Evan G, Litwak, Sara, Sanz‐Villanueva, Laura, Catterall, Tara, Fynch, Stacey, Boon, Louis, Kay, Thomas W, Chee, Jonathan, Krishnamurthy, Balasubramanian, Thomas, Helen E
Publicado 2022

Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes

por Yang, Chieh-Hsin, Ann-Onda, Danise, Lin, Xuzhu, Fynch, Stacey, Nadarajah, Shaktypreya, Pappas, Evan G., Liu, Xin, Scott, John W., Oakhill, Jonathan S., Galic, Sandra, Shi, Yanchuan, Moreno-Asso, Alba, Smith, Cassandra, Loudovaris, Thomas, Levinger, Itamar, Eizirik, Decio L., Laybutt, D. Ross, Herzog, Herbert, Thomas, Helen E., Loh, Kim
Publicado 2021