Diketomorpholines: Synthetic Accessibility and Utilization

por Vu, Lan Phuong, Gütschow, Michael
Publicado 2021

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2

por Mangold, Martin, Gütschow, Michael, Stirnberg, Marit
Publicado 2018

Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots

por Gilberg, Erik, Gütschow, Michael, Bajorath, Jürgen
Publicado 2019

Coumarin as a structural component of substrates and probes for serine and cysteine proteases

por Breidenbach, Julian, Bartz, Ulrike, Gütschow, Michael
Publicado 2020

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis

por Redka, Dar’ya S., Gütschow, Michael, Grinstein, Sergio, Canton, Johnathan
Publicado 2018

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

por Bricelj, Aleša, Steinebach, Christian, Kuchta, Robert, Gütschow, Michael, Sosič, Izidor
Publicado 2021

Structure–Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas

por Keuler, Tim, Ferber, Dominic, Marleaux, Michael, Geyer, Matthias, Gütschow, Michael
Publicado 2022

3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro

por Pászti-Gere, Erzsébet, Szombath, Gergely, Gütschow, Michael, Steinmetzer, Torsten, Székács, András
Publicado 2019

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

por Canton, Johnathan, Schlam, Daniel, Breuer, Christian, Gütschow, Michael, Glogauer, Michael, Grinstein, Sergio
Publicado 2016

Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers

por Küppers, Jim, Schulz-Fincke, Anna Christina, Palus, Jerzy, Giurg, Mirosław, Skarżewski, Jacek, Gütschow, Michael
Publicado 2016

Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

por Pöstges, Florian, Kayser, Kevin, Appelhaus, Jan, Monschke, Marius, Gütschow, Michael, Steinebach, Christian, Wagner, Karl G.
Publicado 2023

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

por Roydeva, Polya G., Beckmann, Anna-Madeleine, Stirnberg, Marit, Cesar, Jožko, Kikelj, Danijel, Ilaš, Janez, Gütschow, Michael
Publicado 2016

2-Amino- and 2-Alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, Interconversion and Enzyme Inhibitory Activities

por Häcker, Hans-Georg, Grundmann, Florian, Lohr, Friederike, Ottersbach, Philipp A., Zhou, Jing, Schnakenburg, Gregor, Gütschow, Michael
Publicado 2009

Development of Fluorescent and Biotin Probes Targeting NLRP3

por Keuler, Tim, Gatterdam, Karl, Akbal, Anil, Lovotti, Marta, Marleaux, Michael, Geyer, Matthias, Latz, Eicke, Gütschow, Michael
Publicado 2021

Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids

por Rivière, Solenne, Vielmuth, Christin, Ennenbach, Christiane, Abdelrahman, Aliaa, Lemke, Carina, Gütschow, Michael, Müller, Christa E., Menche, Dirk
Publicado 2020

Tetrahydroimidazo[1,2‐a]pyrazine Derivatives: Synthesis and Evaluation as Gα(q)‐Protein Ligands

por Küppers, Jim, Benkel, Tobias, Annala, Suvi, Kimura, Kenichi, Reinelt, Lisa, Fleischmann, Bernd K., Kostenis, Evi, Gütschow, Michael
Publicado 2020

Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

por Lemke, Carina, Jílková, Adéla, Ferber, Dominic, Braune, Annett, On, Anja, Johe, Patrick, Zíková, Alena, Schirmeister, Tanja, Mareš, Michael, Horn, Martin, Gütschow, Michael
Publicado 2022

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

por Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael
Publicado 2022

Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins

por Ng, Yuen Lam Dora, Bricelj, Aleša, Jansen, Jacqueline A., Murgai, Arunima, Peter, Kirsten, Donovan, Katherine A., Gütschow, Michael, Krönke, Jan, Steinebach, Christian, Sosič, Izidor
Publicado 2023

Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors

por Geiger, Nina, Diesendorf, Viktoria, Roll, Valeria, König, Eva-Maria, Obernolte, Helena, Sewald, Katherina, Breidenbach, Julian, Pillaiyar, Thanigaimalai, Gütschow, Michael, Müller, Christa E., Bodem, Jochen
Publicado 2023