Skin-Derived ABCB5(+) Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine

por Niebergall-Roth, Elke, Frank, Natasha Y., Ganss, Christoph, Frank, Markus H., Kluth, Mark A.
Publicado 2022

Drug Regulatory-Compliant Validation of a qPCR Assay for Bioanalysis Studies of a Cell Therapy Product with a Special Focus on Matrix Interferences in a Wide Range of Organ Tissues

por Schröder, Hannes M., Niebergall-Roth, Elke, Norrick, Alexandra, Esterlechner, Jasmina, Ganss, Christoph, Frank, Markus H., Kluth, Mark A.
Publicado 2023

Kinetics of Wound Development and Healing Suggests a Skin-Stabilizing Effect of Allogeneic ABCB5(+) Mesenchymal Stromal Cell Treatment in Recessive Dystrophic Epidermolysis Bullosa

por Niebergall-Roth, Elke, Dieter, Kathrin, Daniele, Cristina, Fluhr, Silvia, Khokhrina, Maria, Silva, Ines, Ganss, Christoph, Frank, Markus H., Kluth, Mark A.
Publicado 2023

ABCB5(+) mesenchymal stromal cells therapy protects from hypoxia by restoring Ca(2+) homeostasis in vitro and in vivo

por Yan, Kaixuan, Zheng, Jiaxing, Kluth, Mark Andreas, Li, Lin, Ganss, Christoph, Yard, Benito, Magdeburg, Richard, Frank, Markus H., Pallavi, Prama, Keese, Michael
Publicado 2023

Corrigendum to ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa [Cytotherapy 25 (2023) 782–788/1562]

por Dieter, Kathrin, Niebergall-Roth, Elke, Daniele, Cristina, Fluhr, Silvia, Frank, Natasha Y., Ganss, Christoph, Kiritsi, Dimitra, McGrath, John A., Tolar, Jakub, Frank, Markus H., Kluth, Mark A.
Publicado 2023

ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation

por Meshko, Berbang, Volatier, Thomas L. A., Hadrian, Karina, Deng, Shuya, Hou, Yanhong, Kluth, Mark Andreas, Ganss, Christoph, Frank, Markus H., Frank, Natasha Y., Ksander, Bruce, Cursiefen, Claus, Notara, Maria
Publicado 2023

Process data of allogeneic ex vivo-expanded ABCB5(+) mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP

por Ballikaya, Seda, Sadeghi, Samar, Niebergall-Roth, Elke, Nimtz, Laura, Frindert, Jens, Norrick, Alexandra, Stemler, Nicole, Bauer, Nicole, Rosche, Yvonne, Kratzenberg, Vanessa, Pieper, Julia, Ficek, Tina, Frank, Markus H., Ganss, Christoph, Esterlechner, Jasmina, Kluth, Mark A.
Publicado 2020

Suppression of Neutrophil-Mediated Tissue Damage—A Novel Skill of Mesenchymal Stem Cells

por Jiang, Dongsheng, Muschhammer, Jana, Qi, Yu, Kügler, Andrea, De Vries, Juliane C., Saffarzadeh, Mona, Sindrilaru, Anca, Beken, Seppe Vander, Wlaschek, Meinhard, Kluth, Mark A., Ganss, Christoph, Frank, Natasha Y., Frank, Markus H., Preissner, Klaus T., Scharffetter-Kochanek, Karin
Publicado 2016

Rapid generation of Col7a1(−/−) mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

por Webber, Beau R., O’Connor, Kyle T., McElmurry, Ron T., Durgin, Elise N., Eide, Cindy, Lees, Christopher J., Riddle, Megan J., Mathews, Wendy, Frank, Natasha Y., Kluth, Mark A., Ganss, Christoph, Moriarity, Branden S., Frank, Markus H., Osborn, Mark J., Tolar, Jakub
Publicado 2017

In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials

por TAPPENBECK, NILS, SCHRÖDER, HANNES M., NIEBERGALL-ROTH, ELKE, HASSINGER, FATHEMA, DEHIO, ULF, DIETER, KATHRIN, KRAFT, KORINNA, KERSTAN, ANDREAS, ESTERLECHNER, JASMINA, FRANK, NATASHA Y., SCHARFFETTER-KOCHANEK, KARIN, MURPHY, GEORGE F., ORGILL, DENNIS P., BECK, JOACHIM, FRANK, MARKUS H., GANSS, CHRISTOPH, KLUTH, MARK A.
Publicado 2019

Process development and safety evaluation of ABCB5(+) limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency

por Norrick, Alexandra, Esterlechner, Jasmina, Niebergall-Roth, Elke, Dehio, Ulf, Sadeghi, Samar, Schröder, Hannes M., Ballikaya, Seda, Stemler, Nicole, Ganss, Christoph, Dieter, Kathrin, Dachtler, Ann-Kathrin, Merz, Patrick, Sel, Saadettin, Chodosh, James, Cursiefen, Claus, Frank, Natasha Y., Auffarth, Gerd U., Ksander, Bruce, Frank, Markus H., Kluth, Mark A.
Publicado 2021

Ex vivo-expanded highly pure ABCB5(+) mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process val...

por Kerstan, Andreas, Niebergall-Roth, Elke, Esterlechner, Jasmina, Schröder, Hannes M., Gasser, Martin, Waaga-Gasser, Ana M., Goebeler, Matthias, Rak, Katrin, Schrüfer, Philipp, Endres, Sabrina, Hagenbusch, Petra, Kraft, Korinna, Dieter, Kathrin, Ballikaya, Seda, Stemler, Nicole, Sadeghi, Samar, Tappenbeck, Nils, Murphy, George F., Orgill, Dennis P., Frank, Natasha Y., Ganss, Christoph, Scharffetter-Kochanek, Karin, Frank, Markus H., Kluth, Mark A.
Publicado 2020

Clinical trial of ABCB5(+) mesenchymal stem cells for recessive dystrophic epidermolysis bullosa

por Kiritsi, Dimitra, Dieter, Kathrin, Niebergall-Roth, Elke, Fluhr, Silvia, Daniele, Cristina, Esterlechner, Jasmina, Sadeghi, Samar, Ballikaya, Seda, Erdinger, Leoni, Schauer, Franziska, Gewert, Stella, Laimer, Martin, Bauer, Johann W., Hovnanian, Alain, Zambruno, Giovanna, El Hachem, May, Bourrat, Emmanuelle, Papanikolaou, Maria, Petrof, Gabriela, Kitzmüller, Sophie, Ebens, Christen L., Frank, Markus H., Frank, Natasha Y., Ganss, Christoph, Martinez, Anna E., McGrath, John A., Tolar, Jakub, Kluth, Mark A.
Publicado 2021

Translational development of ABCB5(+) dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

por Kerstan, Andreas, Dieter, Kathrin, Niebergall-Roth, Elke, Klingele, Sabrina, Jünger, Michael, Hasslacher, Christoph, Daeschlein, Georg, Stemler, Lutz, Meyer-Pannwitt, Ulrich, Schubert, Kristin, Klausmann, Gerhard, Raab, Titus, Goebeler, Matthias, Kraft, Korinna, Esterlechner, Jasmina, Schröder, Hannes M., Sadeghi, Samar, Ballikaya, Seda, Gasser, Martin, Waaga-Gasser, Ana M., Murphy, George F., Orgill, Dennis P., Frank, Natasha Y., Ganss, Christoph, Scharffetter-Kochanek, Karin, Frank, Markus H., Kluth, Mark A.
Publicado 2022

Allogeneic ABCB5(+) Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial

por Kerstan, Andreas, Dieter, Kathrin, Niebergall-Roth, Elke, Dachtler, Ann-Kathrin, Kraft, Korinna, Stücker, Markus, Daeschlein, Georg, Jünger, Michael, Görge, Tobias, Meyer-Pannwitt, Ulrich, Erfurt-Berge, Cornelia, von Engelhardt, Charlotte, Klare, Andreas, Pfeiffer, Christiane, Esterlechner, Jasmina, Schröder, Hannes M., Gasser, Martin, Waaga-Gasser, Ana M., Goebeler, Matthias, Ballikaya, Seda, Sadeghi, Samar, Murphy, George F., Orgill, Dennis P., Frank, Natasha Y., Ganss, Christoph, Scharffetter-Kochanek, Karin, Frank, Markus H., Kluth, Mark A.
Publicado 2021