Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

por Parrish, Phoebe C.R., Thomas, James D., Gabel, Austin M., Kamlapurkar, Shriya, Bradley, Robert K., Berger, Alice H.
Publicado 2021

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia

por Park, Jong S, Gabel, Austin M, Kassir, Polina, Kang, Lois, Chowdhary, Prableen K, Osei-Ntansah, Afia, Tran, Neil D, Viswanathan, Soujanya, Canales, Bryanna, Ding, Pengfei, Lee, Young-Sam, Brewster, Rachel
Publicado 2022

RNA isoform screens uncover the essentiality and tumor suppressor activity of ultraconserved poison exons

por Thomas, James D., Polaski, Jacob T., Feng, Qing, De Neef, Emma J., Hoppe, Emma R., McSharry, Maria V., Pangallo, Joseph, Gabel, Austin M., Belleville, Andrea E., Watson, Jacqueline, Nkinsi, Naomi T., Berger, Alice H., Bradley, Robert K.
Publicado 2020

Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells

por North, Khrystyna, Benbarche, Salima, Liu, Bo, Pangallo, Joseph, Chen, Sisi, Stahl, Maximilian, Bewersdorf, Jan Philipp, Stanley, Robert F., Erickson, Caroline, Cho, Hana, Pineda, Jose Mario Bello, Thomas, James D., Polaski, Jacob T., Belleville, Andrea E., Gabel, Austin M., Udy, Dylan B., Humbert, Olivier, Kiem, Hans-Peter, Abdel-Wahab, Omar, Bradley, Robert K.
Publicado 2022

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

por Vichas, Athea, Riley, Amanda K., Nkinsi, Naomi T., Kamlapurkar, Shriya, Parrish, Phoebe C. R., Lo, April, Duke, Fujiko, Chen, Jennifer, Fung, Iris, Watson, Jacqueline, Rees, Matthew, Gabel, Austin M., Thomas, James D., Bradley, Robert K., Lee, John K., Hatch, Emily M., Baine, Marina K., Rekhtman, Natasha, Ladanyi, Marc, Piccioni, Federica, Berger, Alice H.
Publicado 2021