N‐terminal alterations turn the gut hormone GLP‐2 into an antagonist with gradual loss of GLP‐2 receptor selectivity towards more GLP‐1 receptor interaction

por Gabe, Maria Buur Nordskov, Gasbjerg, Lærke Smidt, Gadgaard, Sarina, Lindquist, Peter, Holst, Jens Juul, Rosenkilde, Mette Marie
Publicado 2022

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP sys...

por Gabe, Maria Buur Nordskov, van der Velden, Wijnand J. C., Gadgaard, Sarina, Smit, Florent Xavier, Hartmann, Bolette, Bräuner‐Osborne, Hans, Rosenkilde, Mette Marie
Publicado 2019

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

por Nybo, Maja L., Kvam, Jone M., Nielsen, John E., Frederiksen, Hanne, Spiess, Katja, Jensen, Kristian H. R., Gadgaard, Sarina, Walser, Anna L. S., Thomsen, Jesper S., Cowin, Pamela, Juul, Anders, Jensen, Martin Blomberg, Rosenkilde, Mette M.
Publicado 2023

Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology

por Gadgaard, Sarina, van der Velden, Wijnand J. C., Schiellerup, Sine P., Hunt, Jenna Elizabeth, Gabe, Maria B. N., Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M.
Publicado 2022

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

por Sun, Wen, Chen, Li-Nan, Zhou, Qingtong, Zhao, Li-Hua, Yang, Dehua, Zhang, Huibing, Cong, Zhaotong, Shen, Dan-Dan, Zhao, Fenghui, Zhou, Fulai, Cai, Xiaoqing, Chen, Yan, Zhou, Yan, Gadgaard, Sarina, van der Velden, Wijnand J. C., Zhao, Suwen, Jiang, Yi, Rosenkilde, Mette M., Xu, H. Eric, Zhang, Yan, Wang, Ming-Wei
Publicado 2020