The continuously evolving CRISPR barcoding toolbox

por Gaj, Thomas, Perez-Pinera, Pablo
Publicado 2018

Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies

por Gersbach, Charles A., Gaj, Thomas, Barbas, Carlos F.
Publicado 2014

Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome

por Wallen, Mark C., Gaj, Thomas, Barbas, Carlos F.
Publicado 2015

Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering

por Liu, Jia, Gaj, Thomas, Wallen, Mark C, Barbas, Carlos F
Publicado 2015

Directed evolution of recombinase specificity by split gene reassembly

por Gersbach, Charles A., Gaj, Thomas, Gordley, Russell M., Barbas, Carlos F.
Publicado 2010

Chimeric TALE recombinases with programmable DNA sequence specificity

por Mercer, Andrew C., Gaj, Thomas, Fuller, Roberta P., Barbas, Carlos F.
Publicado 2012

Targeted gene knockout by direct delivery of ZFN proteins

por Gaj, Thomas, Guo, Jing, Kato, Yoshio, Sirk, Shannon J., Barbas, Carlos F.
Publicado 2012

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors

por Perdigão, Pedro, Gaj, Thomas, Santa-Marta, Mariana, Barbas, Carlos F., Goncalves, Joao
Publicado 2016

Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering

por Liu, Jia, Gaj, Thomas, Patterson, James T., Sirk, Shannon J., Barbas III, Carlos F.
Publicado 2014

Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants

por Sirk, Shannon J., Gaj, Thomas, Jonsson, Andreas, Mercer, Andrew C., Barbas, Carlos F.
Publicado 2014

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

por Gersbach, Charles A., Gaj, Thomas, Gordley, Russell M., Mercer, Andrew C., Barbas, Carlos F.
Publicado 2011

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

por Gaj, Thomas, Mercer, Andrew C., Sirk, Shannon J., Smith, Heather L., Barbas, Carlos F.
Publicado 2013

Regulation of Endogenous Human Gene Expression by Ligand-Inducible TALE Transcription Factors

por Mercer, Andrew C., Gaj, Thomas, Sirk, Shannon J., Lamb, Brian M., Barbas, Carlos F.
Publicado 2013

In vivo genome editing improves motor function and extends survival in a mouse model of ALS

por Gaj, Thomas, Ojala, David S., Ekman, Freja K., Byrne, Leah C., Limsirichai, Prajit, Schaffer, David V.
Publicado 2017

CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model

por Ekman, Freja K., Ojala, David S., Adil, Maroof M., Lopez, Paola A., Schaffer, David V., Gaj, Thomas
Publicado 2019

Enhancing the Specificity of Recombinase-Mediated Genome Engineering through Dimer Interface Redesign

por Gaj, Thomas, Sirk, Shannon J., Tingle, Ryan D., Mercer, Andrew C., Wallen, Mark C., Barbas, Carlos F.
Publicado 2014

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

por Zeballos C, M. Alejandra, Moore, Hayden J., Smith, Tyler J., Powell, Jackson E., Ahsan, Najah S., Zhang, Sijia, Gaj, Thomas
Publicado 2023

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

por Zeballos C., M. Alejandra, Moore, Hayden J., Smith, Tyler J., Powell, Jackson E., Ahsan, Najah S., Zhang, Sijia, Gaj, Thomas
Publicado 2023

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

por Gaj, Thomas, Staahl, Brett T., Rodrigues, Gonçalo M. C., Limsirichai, Prajit, Ekman, Freja K., Doudna, Jennifer A., Schaffer, David V.
Publicado 2017

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model

por Adil, Maroof M., Gaj, Thomas, Rao, Antara T., Kulkarni, Rishikesh U., Fuentes, Christina M., Ramadoss, Gokul N., Ekman, Freja K., Miller, Evan W., Schaffer, David V.
Publicado 2018