Therapeutic targeting of transcriptional cyclin-dependent kinases

por Galbraith, Matthew D., Bender, Heather, Espinosa, Joaquín M.
Publicado 2018

Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology

por Donovan, Micah G., Galbraith, Matthew D., Espinosa, Joaquin M.
Publicado 2022

Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

por Andrysik, Zdenek, Bender, Heather, Galbraith, Matthew D., Espinosa, Joaquin M.
Publicado 2021

Mechanisms of transcriptional regulation by p53

por Sullivan, Kelly D, Galbraith, Matthew D, Andrysik, Zdenek, Espinosa, Joaquin M
Publicado 2018

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

por Henry, Ryan E, Andrysik, Zdenek, París, Ramiro, Galbraith, Matthew D, Espinosa, Joaquín M
Publicado 2012

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1

por Galbraith, Matthew D., Saxton, Janice, Li, Li, Shelton, Samuel J., Zhang, Hongmei, Espinosa, Joaquin M., Shaw, Peter E.
Publicado 2013

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response

por Audetat, K. Audrey, Galbraith, Matthew D., Odell, Aaron T., Lee, Thomas, Pandey, Ahwan, Espinosa, Joaquin M., Dowell, Robin D., Taatjes, Dylan J.
Publicado 2017

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity

por Andrysik, Zdenek, Galbraith, Matthew D., Guarnieri, Anna L., Zaccara, Sara, Sullivan, Kelly D., Pandey, Ahwan, MacBeth, Morgan, Inga, Alberto, Espinosa, Joaquín M.
Publicado 2017

Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway

por Ludwig, Michael P., Galbraith, Matthew D., Eduthan, Neetha Paul, Hill, Amanda A., Clay, Michael R., Tellez, Cristiam Moreno, Wilky, Breelyn A., Elias, Anthony, Espinosa, Joaquin M., Sullivan, Kelly D.
Publicado 2023

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment

por D’Alessandro, Angelo, Nouraie, S. Mehdi, Zhang, Yingze, Cendali, Francesca, Gamboni, Fabia, Reisz, Julie A., Zhang, Xu, Bartsch, Kyle W., Galbraith, Matthew D., Espinosa, Joaquin M., Gordeuk, Victor R., Gladwin, Mark T.
Publicado 2023

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

por Cozzolino, Kira, Sanford, Lynn, Hunter, Samuel, Molison, Kayla, Erickson, Benjamin, Jones, Taylor, Ajit, Deepa, Galbraith, Matthew D., Espinosa, Joaquin M., Bentley, David L., Allen, Mary A., Dowell, Robin D., Taatjes, Dylan J.
Publicado 2023

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

por Allen, Mary Ann, Andrysik, Zdenek, Dengler, Veronica L, Mellert, Hestia S, Guarnieri, Anna, Freeman, Justin A, Sullivan, Kelly D, Galbraith, Matthew D, Luo, Xin, Kraus, W Lee, Dowell, Robin D, Espinosa, Joaquin M
Publicado 2014

FAM193A is a positive regulator of p53 activity

por Szwarc, Maria M., Guarnieri, Anna L., Joshi, Molishree, Duc, Huy N., Laird, Madison C., Pandey, Ahwan, Khanal, Santosh, Dohm, Emily, Bui, Aimee K., Sullivan, Kelly D., Galbraith, Matthew D., Andrysik, Zdenek, Espinosa, Joaquin M.
Publicado 2023

Trisomy 21 consistently activates the interferon response

por Sullivan, Kelly D, Lewis, Hannah C, Hill, Amanda A, Pandey, Ahwan, Jackson, Leisa P, Cabral, Joseph M, Smith, Keith P, Liggett, L Alexander, Gomez, Eliana B, Galbraith, Matthew D, DeGregori, James, Espinosa, Joaquín M
Publicado 2016

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation

por Tatavosian, Roubina, Donovan, Micah G., Galbraith, Matthew D., Duc, Huy N., Szwarc, Maria M., Joshi, Molishree U., Frieman, Amy, Bilousova, Ganna, Cao, Yingqiong, Smith, Keith P., Song, Kunhua, Rachubinski, Angela L., Andrysik, Zdenek, Espinosa, Joaquin M.
Publicado 2023

IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome

por Araya, Paula, Kinning, Kohl T., Coughlan, Christina, Smith, Keith P., Granrath, Ross E., Enriquez-Estrada, Belinda A., Worek, Kayleigh, Sullivan, Kelly D., Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Galbraith, Matthew D., Potter, Huntington, Espinosa, Joaquin M.
Publicado 2022

Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition

por Galbraith, Matthew D., Rachubinski, Angela L., Smith, Keith P., Araya, Paula, Waugh, Katherine A., Enriquez-Estrada, Belinda, Worek, Kayleigh, Granrath, Ross E., Kinning, Kohl T., Paul Eduthan, Neetha, Ludwig, Michael P., Hsieh, Elena W. Y., Sullivan, Kelly D., Espinosa, Joaquin M.
Publicado 2023

Seroconversion stages COVID19 into distinct pathophysiological states

por Galbraith, Matthew D., Kinning, Kohl T., Sullivan, Kelly D., Baxter, Ryan, Araya, Paula, Jordan, Kimberly R., Russell, Seth, Smith, Keith P., Granrath, Ross E., Shaw, Jessica, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A., D’Alessandro, Angelo, Hansen, Kirk C., Bennett, Tellen D., Hsieh, Elena W.Y., Espinosa, Joaquin M.
Publicado 2020

Seroconversion stages COVID19 into distinct pathophysiological states

por Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Baxter, Ryan, Araya, Paula, Jordan, Kimberly R, Russell, Seth, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A, D'Alessandro, Angelo, Hansen, Kirk C, Benett, Tellen D, Hsieh, Elena WY, Espinosa, Joaquín M
Publicado 2021

The COVIDome Explorer Researcher Portal

por Sullivan, Kelly D., Galbraith, Matthew D., Kinning, Kohl T., Bartsch, Kyle, Levinsky, Nik, Araya, Paula, Smith, Keith P., Granrath, Ross E., Shaw, Jessica R., Baxter, Ryan, Jordan, Kimberly R., Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A., Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Monte, Andrew A., Bennett, Tellen D., Miller, Michael G., Hsieh, Elena W.Y., D’Alessandro, Angelo, Hansen, Kirk C., Espinosa, Joaquin M.
Publicado 2021