Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

por Obaji, Ezeogo, Maksimainen, Mirko M., Galera-Prat, Albert, Lehtiö, Lari
Publicado 2021

Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity

por Galera-Prat, Albert, Alaviuhkola, Juho, Alanen, Heli I, Lehtiö, Lari
Publicado 2022

An Evolutionary Perspective on the Origin, Conservation and Binding Partner Acquisition of Tankyrases

por Sowa, Sven T., Bosetti, Chiara, Galera-Prat, Albert, Johnson, Mark S., Lehtiö, Lari
Publicado 2022

Nanomechanics of tip-link cadherins

por Oroz, Javier, Galera-Prat, Albert, Hervás, Rubén, Valbuena, Alejandro, Fernández-Bravo, Débora, Carrión-Vázquez, Mariano
Publicado 2019

A molecular toolbox for ADP-ribosyl binding proteins

por Sowa, Sven T., Galera-Prat, Albert, Wazir, Sarah, Alanen, Heli I., Maksimainen, Mirko M., Lehtiö, Lari
Publicado 2021

Preparation of screening assays for ADP-ribosyl readers and erasers using the GAP-tag as a binding probe

por Sowa, Sven T., Galera-Prat, Albert, Wazir, Sarah, Alanen, Heli I., Maksimainen, Mirko M., Lehtiö, Lari
Publicado 2022

Transcytosis in the blood–cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system

por Méndez-Gómez, Héctor R, Galera-Prat, Albert, Meyers, Craig, Chen, Weijun, Singh, Jasbir, Carrión-Vázquez, Mariano, Muzyczka, Nicholas
Publicado 2015

A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases

por Sowa, Sven T., Vela-Rodríguez, Carlos, Galera-Prat, Albert, Cázares-Olivera, Mariana, Prunskaite-Hyyryläinen, Renata, Ignatev, Alexander, Lehtiö, Lari
Publicado 2020

Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

por Hervás, Rubén, del Carmen Fernández-Ramírez, María, Galera-Prat, Albert, Suzuki, Mari, Nagai, Yoshitaka, Bruix, Marta, Menéndez, Margarita, Laurents, Douglas V., Carrión-Vázquez, Mariano
Publicado 2021

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10

por Korn, Patricia, Classen, Arno, Murthy, Sudarshan, Guareschi, Riccardo, Maksimainen, Mirko M., Lippok, Barbara E., Galera‐Prat, Albert, Sowa, Sven T., Voigt, Catharina, Rossetti, Giulia, Lehtiö, Lari, Bolm, Carsten, Lüscher, Bernhard
Publicado 2021

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

por Waaler, Jo, Leenders, Ruben G. G., Sowa, Sven T., Alam Brinch, Shoshy, Lycke, Max, Nieczypor, Piotr, Aertssen, Sjoerd, Murthy, Sudarshan, Galera-Prat, Albert, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Krauss, Stefan
Publicado 2020

Common Features at the Start of the Neurodegeneration Cascade

por Hervás, Rubén, Oroz, Javier, Galera-Prat, Albert, Goñi, Oscar, Valbuena, Alejandro, Vera, Andrés M., Gómez-Sicilia, Àngel, Losada-Urzáiz, Fernando, Uversky, Vladimir N., Menéndez, Margarita, Laurents, Douglas V., Bruix, Marta, Carrión-Vázquez, Mariano
Publicado 2012

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

por Leenders, Ruben G. G., Brinch, Shoshy Alam, Sowa, Sven T., Amundsen-Isaksen, Enya, Galera-Prat, Albert, Murthy, Sudarshan, Aertssen, Sjoerd, Smits, Johannes N., Nieczypor, Piotr, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Waaler, Jo, Krauss, Stefan
Publicado 2021

[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes

por Murthy, Sudarshan, Nizi, Maria Giulia, Maksimainen, Mirko M., Massari, Serena, Alaviuhkola, Juho, Lippok, Barbara E., Vagaggini, Chiara, Sowa, Sven T., Galera-Prat, Albert, Ashok, Yashwanth, Venkannagari, Harikanth, Prunskaite-Hyyryläinen, Renata, Dreassi, Elena, Lüscher, Bernhard, Korn, Patricia, Tabarrini, Oriana, Lehtiö, Lari
Publicado 2023

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation

por Hervás, Rubén, Li, Liying, Majumdar, Amitabha, Fernández-Ramírez, María del Carmen, Unruh, Jay R., Slaughter, Brian D., Galera-Prat, Albert, Santana, Elena, Suzuki, Mari, Nagai, Yoshitaka, Bruix, Marta, Casas-Tintó, Sergio, Menéndez, Margarita, Laurents, Douglas V., Si, Kausik, Carrión-Vázquez, Mariano
Publicado 2016

The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models

por Brinch, Shoshy A., Amundsen-Isaksen, Enya, Espada, Sandra, Hammarström, Clara, Aizenshtadt, Aleksandra, Olsen, Petter A., Holmen, Lone, Høyem, Merete, Scholz, Hanne, Grødeland, Gunnveig, Sowa, Sven T., Galera-Prat, Albert, Lehtiö, Lari, Meerts, Ilonka A.T.M., Leenders, Ruben G.G., Wegert, Anita, Krauss, Stefan, Waaler, Jo
Publicado 2022