Development of an Effective Therapy for Alkaptonuria – Lessons for Osteoarthritis

por Gallagher, James A., Dillon, Jane P., Ranganath, Lakshminarayan R.
Publicado 2021

An unusual example of hereditary multiple exostoses: a case report and review of the literature

por Chilvers, Rebecca, Gallagher, James A., Jeffery, Nathan, Bond, Alistair P.
Publicado 2021

“Lessons from Rare Forms of Osteoarthritis”

por Shepherd, Rebecca F., Kerns, Jemma G., Ranganath, Lakshminarayan R., Gallagher, James A., Taylor, Adam M.
Publicado 2021

Receptors and effects of gut hormones in three osteoblastic cell lines

por Pacheco-Pantoja, Elda L, Ranganath, Lakshminarayan R, Gallagher, James A, Wilson, Peter JM, Fraser, William D
Publicado 2011

Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2‐dioxygenase deficiency in the liver is responsible for homogentisic acid‐derived ochronotic pigme...

por Wilson, Peter J. M., Ranganath, Lakshminarayan R., Bou‐Gharios, George, Gallagher, James A., Hughes, Juliette H.
Publicado 2020

Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria

por Davison, Andrew S., Norman, Brendan P., Sutherland, Hazel, Milan, Anna M., Gallagher, James A., Jarvis, Jonathan C., Ranganath, Lakshminarayan R.
Publicado 2022

Concentric lamellae – novel microanatomical structures in the articular calcified cartilage of mice

por Keenan, Craig M., Beckett, Alison J., Sutherland, Hazel, Ranganath, Lakshminarayan R., Jarvis, Jonathan C., Prior, Ian A., Gallagher, James A.
Publicado 2019

Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial

por Ooi, Nicola, Cooper, Ian R., Norman, Brendan, Gallagher, James A., Sireau, Nick, Bou-Gharios, George, Ranganath, Lakshminarayan R., Savage, Victoria J.
Publicado 2023

Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS

por Davison, Andrew S., Norman, Brendan P., Ross, Gordon A., Hughes, Andrew T., Khedr, Milad, Milan, Anna M., Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2019

Reversal of ochronotic pigmentation in alkaptonuria following nitisinone therapy: Analysis of data from the United Kingdom National Alkaptonuria Centre

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Davison, Andrew S., Wilson, Peter J., Dillon, Jane P., West, Elizabeth, Gallagher, James A.
Publicado 2020

Increased prevalence of Parkinson's disease in alkaptonuria

por Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.
Publicado 2023

Nitisinone Treatment Affects Biomarkers of Bone and Cartilage Remodelling in Alkaptonuria Patients

por Genovese, Federica, Frederiksen, Peder, Bay-Jensen, Anne-Christine, Karsdal, Morten A., Milan, Anna M., Olsson, Birgitta, Rudebeck, Mattias, Gallagher, James A., Ranganath, Lakshminarayan R.
Publicado 2023

Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage

por Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut
Publicado 2020

Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

por Gartland, Alison, Skarratt, Kristen K, Hocking, Lynne J, Parsons, Claire, Stokes, Leanne, Jørgensen, Niklas Rye, Fraser, William D, Reid, David M, Gallagher, James A, Wiley, James S
Publicado 2012

Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard
Publicado 2021

Defining the Properties of an Array of –NH(2)-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Cont...

por Fawcett, Sandra A., Curran, Judith M., Chen, Rui, Rhodes, Nicholas P., Murphy, Mark F., Wilson, Peter, Ranganath, Lakshminarayan, Dillon, Jane P., Gallagher, James A., Hunt, John A.
Publicado 2016

Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces

por Hughes, Juliette H., Keenan, Craig M., Sutherland, Hazel, Edwards, Henry R., Wilson, Peter J. M., Ranganath, Lakshminarayan R., Jarvis, Jonathan C., Bou-Gharios, George, Gallagher, James A.
Publicado 2020

Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen...

por Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A.
Publicado 2022

Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria

por Ranganath, Lakshminarayan R., Hughes, Andrew T., Davison, Andrew S., Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P., Bou-Gharios, George, Gallagher, James A., Milan, Anna M.
Publicado 2022

Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria

por Hughes, Juliette H., Wilson, Peter J. M., Sutherland, Hazel, Judd, Shirley, Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Bou‐Gharios, George, Ranganath, Lakshminarayan R., Gallagher, James A.
Publicado 2020