Mitochondrial DNA: the overlooked oncogenome?

por Gammage, Payam A., Frezza, Christian
Publicado 2019

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome

por Rorbach, Joanna, Gammage, Payam A., Minczuk, Michal
Publicado 2012

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome

por Rorbach, Joanna, Gammage, Payam A., Minczuk, Michal
Publicado 2016

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

por Gammage, Payam A., Moraes, Carlos T., Minczuk, Michal
Publicado 2018

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

por Gammage, Payam A, Rorbach, Joanna, Vincent, Anna I, Rebar, Edward J, Minczuk, Michal
Publicado 2014

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

por Hoitzing, Hanne, Gammage, Payam A., Haute, Lindsey Van, Minczuk, Michal, Johnston, Iain G., Jones, Nick S.
Publicado 2019

MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome

por Rorbach, Joanna, Boesch, Pierre, Gammage, Payam A., Nicholls, Thomas J. J., Pearce, Sarah F., Patel, Dipali, Hauser, Andreas, Perocchi, Fabiana, Minczuk, Michal
Publicado 2014

Alternative translation initiation augments the human mitochondrial proteome

por Kazak, Lawrence, Reyes, Aurelio, Duncan, Anna L., Rorbach, Joanna, Wood, Stuart R., Brea-Calvo, Gloria, Gammage, Payam A., Robinson, Alan J., Minczuk, Michal, Holt, Ian J.
Publicado 2013

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

por Gaude, Edoardo, Schmidt, Christina, Gammage, Payam A., Dugourd, Aurelien, Blacker, Thomas, Chew, Sew Peak, Saez-Rodriguez, Julio, O’Neill, John S., Szabadkai, Gyorgy, Minczuk, Michal, Frezza, Christian
Publicado 2018

PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness

por Rabas, Nicolas, Palmer, Sarah, Mitchell, Louise, Ismail, Shehab, Gohlke, Andrea, Riley, Joel S., Tait, Stephen W.G., Gammage, Payam, Soares, Leandro Lemgruber, Macpherson, Iain R., Norman, Jim C.
Publicado 2021

Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family

por Kullar, Peter J, Gomez-Duran, Aurora, Gammage, Payam A, Garone, Caterina, Minczuk, Michal, Golder, Zoe, Wilson, Janet, Montoya, Julio, Häkli, Sanna, Kärppä, Mikko, Horvath, Rita, Majamaa, Kari, Chinnery, Patrick F
Publicado 2018

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

por Peeva, Viktoriya, Blei, Daniel, Trombly, Genevieve, Corsi, Sarah, Szukszto, Maciej J., Rebelo-Guiomar, Pedro, Gammage, Payam A., Kudin, Alexei P., Becker, Christian, Altmüller, Janine, Minczuk, Michal, Zsurka, Gábor, Kunz, Wolfram S.
Publicado 2018

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

por Gammage, Payam A., Gaude, Edoardo, Van Haute, Lindsey, Rebelo-Guiomar, Pedro, Jackson, Christopher B., Rorbach, Joanna, Pekalski, Marcin L., Robinson, Alan J., Charpentier, Marine, Concordet, Jean-Paul, Frezza, Christian, Minczuk, Michal
Publicado 2016

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

por Gammage, Payam A., Viscomi, Carlo, Simard, Marie-Lune, Costa, Ana S.H., Gaude, Edoardo, Powell, Christopher A., Van Haute, Lindsey, McCann, Beverly J., Rebelo-Guiomar, Pedro, Cerutti, Raffaele, Zhang, Lei, Rebar, Edward J., Zeviani, Massimo, Frezza, Christian, Stewart, James B., Minczuk, Michal
Publicado 2018

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

por Andreazza, Simonetta, Samstag, Colby L., Sanchez-Martinez, Alvaro, Fernandez-Vizarra, Erika, Gomez-Duran, Aurora, Lee, Juliette J., Tufi, Roberta, Hipp, Michael J., Schmidt, Elizabeth K., Nicholls, Thomas J., Gammage, Payam A., Chinnery, Patrick F., Minczuk, Michal, Pallanck, Leo J., Kennedy, Scott R., Whitworth, Alexander J.
Publicado 2019

Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma

por Ganly, Ian, Liu, Eric Minwei, Kuo, Fengshen, Makarov, Vladimir, Dong, Yiyu, Park, Jinsung, Gong, Yongxing, Gorelick, Alexander N., Knauf, Jeffrey A, Benedetti, Elisa, Tait-Mulder, Jacqueline, Morris, Luc G.T., Fagin, James A., Intlekofer, Andrew M, Krumsiek, Jan, Gammage, Payam A., Ghossein, Ronald, Xu, Bin, Chan, Timothy A., Reznik, Ed
Publicado 2022

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

por Mahmood, Mahnoor, Liu, Eric Minwei, Shergold, Amy L., Tolla, Elisabetta, Tait-Mulder, Jacqueline, Huerta Uribe, Alejandro, Shokry, Engy, Young, Alex L., Lilla, Sergio, Kim, Minsoo, Park, Tricia, Manchon, J.L., Rodríguez-Antona, Crístina, Walters, Rowan C., Springett, Roger J., Blaza, James N., Zanivan, Sara, Sumpton, David, Roberts, Edward W., Reznik, Ed, Gammage, Payam A.
Publicado 2023