Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabeti...

por Cortese, Giuliana, Gandasi, Nikhil R., Barg, Sebastian, Pedersen, Morten Gram
Publicado 2016

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?

por Makam, Aishwarya A., Biswas, Anusmita, Kothegala, Lakshmi, Gandasi, Nikhil R.
Publicado 2022

Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes

por Kothegala, Lakshmi, Miranda, Caroline, Singh, Meetu, Krieger, Jean-Philippe, Gandasi, Nikhil R.
Publicado 2023

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

por Gandasi, Nikhil R., Vestö, Kim, Helou, Maria, Yin, Peng, Saras, Jan, Barg, Sebastian
Publicado 2015

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

por Petrenko, Volodymyr, Gandasi, Nikhil R., Sage, Daniel, Tengholm, Anders, Barg, Sebastian, Dibner, Charna
Publicado 2020

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

por Omar-Hmeadi, Muhmmad, Lund, Per-Eric, Gandasi, Nikhil R., Tengholm, Anders, Barg, Sebastian
Publicado 2020

Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells

por Hatamie, Amir, Ren, Lin, Dou, Haiqiang, Gandasi, Nikhil R., Rorsman, Patrik, Ewing, Andrew
Publicado 2021

Syntaxin clusters at secretory granules in a munc18-bound conformation

por Yin, Peng, Gandasi, Nikhil R., Arora, Swati, Omar-Hmeadi, Muhmmad, Saras, Jan, Barg, Sebastian
Publicado 2018

The PI(4)P phosphatase Sac2 controls insulin granule docking and release

por Nguyen, Phuoc My, Gandasi, Nikhil R., Xie, Beichen, Sugahara, Sari, Xu, Yingke, Idevall-Hagren, Olof
Publicado 2019

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

por Guček, Alenka, Gandasi, Nikhil R, Omar-Hmeadi, Muhmmad, Bakke, Marit, Døskeland, Stein O, Tengholm, Anders, Barg, Sebastian
Publicado 2019

Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine–Glutamate Cycle

por Gandasi, Nikhil R., Arapi, Vasiliki, Mickael, Michel E., Belekar, Prajakta A., Granlund, Louise, Kothegala, Lakshmi, Fredriksson, Robert, Bagchi, Sonchita
Publicado 2021

Ca(2+) channel clustering with insulin-containing granules is disturbed in type 2 diabetes

por Gandasi, Nikhil R., Yin, Peng, Riz, Michela, Chibalina, Margarita V., Cortese, Giuliana, Lund, Per-Eric, Matveev, Victor, Rorsman, Patrik, Sherman, Arthur, Pedersen, Morten G., Barg, Sebastian
Publicado 2017

MiR‐335 overexpression impairs insulin secretion through defective priming of insulin vesicles

por Salunkhe, Vishal A., Ofori, Jones K., Gandasi, Nikhil R., Salö, Sofia A., Hansson, Sofia, Andersson, Markus E., Wendt, Anna, Barg, Sebastian, Esguerra, Jonathan L. S., Eliasson, Lena
Publicado 2017

Functional Characterization of Native, High-Affinity GABA(A) Receptors in Human Pancreatic β Cells

por Korol, Sergiy V., Jin, Zhe, Jin, Yang, Bhandage, Amol K., Tengholm, Anders, Gandasi, Nikhil R., Barg, Sebastian, Espes, Daniel, Carlsson, Per-Ola, Laver, Derek, Birnir, Bryndis
Publicado 2018

Global loss of cellular m(6)A RNA methylation following infection with different SARS-CoV-2 variants

por Vaid, Roshan, Mendez, Akram, Thombare, Ketan, Burgos-Panadero, Rebeca, Robinot, Rémy, Fonseca, Barbara F., Gandasi, Nikhil R., Ringlander, Johan, Hassan Baig, Mohammad, Dong, Jae-June, Cho, Jae Yong, Reinius, Björn, Chakrabarti, Lisa A., Nystrom, Kristina, Mondal, Tanmoy
Publicado 2023