Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration

por Ayyadevara, Srinivas, Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Shmookler Reis, Robert J.
Publicado 2021

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Publicado 2022

Protein homeostasis in the aged and diseased heart

por Mainali, Nirjal, Ayyadevara, Srinivas, Ganne, Akshatha, Shmookler Reis, Robert J., Mehta, Jawahar L.
Publicado 2023

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Griffin, W. Sue T., Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

por Shmookler Reis, Robert J., Atluri, Ramani, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Ganne, Akshatha, Ayyadevara, Srinivas
Publicado 2021

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Mainali, Nirjal, Atluri, Paavan, Shmookler Reis, Robert J., Ayyadevara, Srinivas
Publicado 2022

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

por Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Haarika, Kiaei, Lily, Shmookler Reis, Robert J., Varughese, Kottayil I., Kiaei, Mahmoud
Publicado 2023

Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases

por Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Ganne, Akshatha, Kakraba, Samuel, Penthala, Narsimha Reddy, Du, Xiuxia, Crooks, Peter A., Griffin, Sue T., Shmookler Reis, Robert J.
Publicado 2019

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

por Kakraba, Samuel, Ayyadevara, Srinivas, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Ganne, Akshatha, Liu, Ling, Alla, Ramani, Bommagani, Shoban Babu, Barger, Steven W., Griffin, W. Sue T., Crooks, Peter A., Shmookler Reis, Robert J.
Publicado 2019