Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice

por Spetea, Mariana, Eans, Shainnel O, Ganno, Michelle L, Lantero, Aquilino, Mairegger, Michael, Toll, Lawrence, Schmidhammer, Helmut, McLaughlin, Jay P
Publicado 2017

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

por McLaughlin, Jay P., Rayala, Ramanjaneyulu, Bunnell, Ashley J., Tantak, Mukund P., Eans, Shainnel O., Nefzi, Khadija, Ganno, Michelle L., Dooley, Colette T., Nefzi, Adel
Publicado 2022

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

por Brice-Tutt, Ariana C., Senadheera, Sanjeewa N., Ganno, Michelle L., Eans, Shainnel O., Khaliq, Tanvir, Murray, Thomas F., McLaughlin, Jay P., Aldrich, Jane V.
Publicado 2020

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping

por Khera, Eshita, Cilliers, Cornelius, Smith, Michael D., Ganno, Michelle L., Lai, Katharine C., Keating, Thomas A., Kopp, Anna, Nessler, Ian, Abu-Yousif, Adnan O., Thurber, Greg M.
Publicado 2020

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

por Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Publicado 2015