Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site

por Kumar, Amit, Mao, Shenlan, Dimasi, Nazzareno, Gao, Changshou
Publicado 2020

Structural characterization of a human Fc fragment engineered for lack of effector functions

por Oganesyan, Vaheh, Gao, Changshou, Shirinian, Lena, Wu, Herren, Dall’Acqua, William F.
Publicado 2008

An antidote approach to reduce risk and broaden utility of antibody-based therapeutics

por Portnoff, Alyse D., Gao, Cuihua, Borrok, M. Jack, Gao, Xizhe, Gao, Changshou, Rainey, G. Jonah
Publicado 2017

Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs

por Kumar, Amit, Kinneer, Krista, Masterson, Luke, Ezeadi, Ebele, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Publicado 2018

Fab-Arm Exchange Combined with Selective Protein A Purification Results in a Platform for Rapid Preparation of Monovalent Bispecific Antibodies Directly from Culture Media

por Steinhardt, James, Wu, Yanli, Fleming, Ryan, Ruddle, Ben T., Patel, Pooja, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Publicado 2019

Molecular basis for the mechanism of action of an anti-TACE antibody

por Peng, Li, Cook, Kimberly, Xu, Linda, Cheng, Li, Damschroder, Melissa, Gao, Changshou, Wu, Herren, Dall'Acqua, William F.
Publicado 2016

Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach

por VanDyke, Derek, Xu, Linda, Sargunas, Paul R., Gilbreth, Ryan N., Baca, Manuel, Gao, Changshou, Hunt, James, Spangler, Jamie B.
Publicado 2023

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format

por Xiao, Xiaodong, Chen, Yan, Mugabe, Sheila, Gao, Changshou, Tkaczyk, Christine, Mazor, Yariv, Pavlik, Peter, Wu, Herren, Dall’Acqua, William, Chowdhury, Partha Sarathi
Publicado 2015

Germinal Center B Cell Depletion Diminishes CD4(+) Follicular T Helper Cells in Autoimmune Mice

por Yusuf, Isharat, Stern, Jessica, McCaughtry, Tom M., Gallagher, Sandra, Sun, Hong, Gao, Changshou, Tedder, Thomas, Carlesso, Gianluca, Carter, Laura, Herbst, Ronald, Wang, Yue
Publicado 2014

Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production

por Kurasawa, James H., Park, Andrew, Sowers, Carrie R., Halpin, Rebecca A., Tovchigrechko, Andrey, Dobson, Claire L., Schmelzer, Albert E., Gao, Changshou, Wilson, Susan D., Ikeda, Yasuhiro
Publicado 2020

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

por Kasturirangan, Srinath, Rainey, G. Jonah, Xu, Linda, Wang, Xinwei, Portnoff, Alyse, Chen, Tracy, Fazenbaker, Christine, Zhong, Helen, Bee, Jared, Zeng, Zhutian, Jenne, Craig, Wu, Herren, Gao, Changshou
Publicado 2017

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

por Christie, R. James, Tiberghien, Arnaud C., Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip W., Gao, Changshou
Publicado 2017

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

por Oganesyan, Vaheh, Peng, Li, Bee, Jared S., Li, John, Perry, Samuel R., Comer, Frank, Xu, Linda, Cook, Kimberly, Senthil, Kannaki, Clarke, Lori, Rosenthal, Kim, Gao, Changshou, Damschroder, Melissa, Wu, Herren, Dall'Acqua, William
Publicado 2018

Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance

por Zou, Jia, Li, Li, Zheng, Peiyi, Liang, Wenhua, Hu, Siyi, Zhou, Shuaixiang, Wang, Yanqun, Zhao, Jincun, Yuan, Daopeng, Liu, Lu, Wu, Dongdong, Xu, Mengqiu, Zhang, Fangfang, Zhu, Mengzhu, Wu, Zhihai, Cao, Xiaochao, Ni, Meng, Ling, Xiaomin, Wu, Yue, Kuang, Zhihui, Hu, Moyan, Li, Jianfeng, Li, Xue, Guo, Xiling, Xu, Tianmin, Jiang, Haiping, Gao, Changshou, Yu, Michael, Liu, Junjian, Zhong, Nanshan, Zhou, Jianfeng, Huang, Jian-an, Jin, Tengchuan, He, Jianxing
Publicado 2022