Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

por Gao, Yongzhi, van Haren, Matthijs J., Moret, Ed E., Rood, Johannes J. M., Sartini, Davide, Salvucci, Alessia, Emanuelli, Monica, Craveur, Pierrick, Babault, Nicolas, Jin, Jian, Martin, Nathaniel I.
Publicado 2019

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

por van Haren, Matthijs J., Gao, Yongzhi, Buijs, Ned, Campagna, Roberto, Sartini, Davide, Emanuelli, Monica, Mateuszuk, Lukasz, Kij, Agnieszka, Chlopicki, Stefan, Escudé Martinez de Castilla, Pol, Schiffelers, Raymond, Martin, Nathaniel I.
Publicado 2021

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)

por van Haren, Matthijs J., Zhang, Yurui, Thijssen, Vito, Buijs, Ned, Gao, Yongzhi, Mateuszuk, Lukasz, Fedak, Filip A., Kij, Agnieszka, Campagna, Roberto, Sartini, Davide, Emanuelli, Monica, Chlopicki, Stefan, Jongkees, Seino A. K., Martin, Nathaniel I.
Publicado 2021

Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics

por Gao, Yongzhi, van Haren, Matthijs J., Buijs, Ned, Innocenti, Paolo, Zhang, Yurui, Sartini, Davide, Campagna, Roberto, Emanuelli, Monica, Parsons, Richard B., Jespers, Willem, Gutiérrez-de-Terán, Hugo, van Westen, Gerard J. P., Martin, Nathaniel I.
Publicado 2021