Enhanced channel activity by PI(4,5)P(2) ignites MLKL-related pathogenic processes

por Xia, Bingqing, Qie, Jingbo, Shen, Xurui, Wang, Sheng, Gao, Zhaobing
Publicado 2022

Activation of peripheral KCNQ channels relieves gout pain

por Zheng, Yueming, Xu, Haiyan, Zhan, Li, Zhou, Xindi, Chen, Xueqin, Gao, Zhaobing
Publicado 2015

Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants

por Zheng, Yueming, Zhu, Xuejing, Zhou, Pingzheng, Lan, Xi, Xu, Haiyan, Li, Min, Gao, Zhaobing
Publicado 2012

MLKL forms cation channels

por Xia, Bingqing, Fang, Sui, Chen, Xueqin, Hu, Hong, Chen, Peiyuan, Wang, Huayi, Gao, Zhaobing
Publicado 2016

High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice

por Yin, Xianzhen, Zhang, Xiaochuan, Zhang, Jingjing, Yang, Weicheng, Sun, Xian, Zhang, Haiyan, Gao, Zhaobing, Jiang, Hualiang
Publicado 2022

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors

por Zeng, Yue, Zheng, Yueming, Zhang, Tongtong, Ye, Fei, Zhan, Li, Kou, Zengwei, Zhu, Shujia, Gao, Zhaobing
Publicado 2022

A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

por Bai, Fang, Pi, Xiaoping, Li, Ping, Zhou, Pingzheng, Yang, Huaiyu, Wang, Xicheng, Li, Min, Gao, Zhaobing, Jiang, Hualiang
Publicado 2018

High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice

por Zhang, Xiaochuan, Yin, Xianzhen, Zhang, Jingjing, Li, Anan, Gong, Hui, Luo, Qingming, Zhang, Haiyan, Gao, Zhaobing, Jiang, Hualiang
Publicado 2019

Why is the SARS-CoV-2 Omicron variant milder?

por Xia, Bingqing, Wang, Yi, Pan, Xiaoyan, Cheng, Xi, Ji, Hongying, Zuo, Xiaoli, Jiang, Hualiang, Li, Jia, Gao, Zhaobing
Publicado 2022

Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB

por Wang, Yi, Pan, Xiaoyan, Ji, Hongying, Zuo, Xiaoli, Xiao, Geng-Fu, Li, Jia, Zhang, Lei-Ke, Xia, Bingqing, Gao, Zhaobing
Publicado 2023

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

por Li, Ping, Chen, Zhuxi, Xu, Haiyan, Sun, Haifeng, Li, Hao, Liu, Hong, Yang, Huaiyu, Gao, Zhaobing, Jiang, Hualiang, Li, Min
Publicado 2013

TRPA1 channel mediates organophosphate-induced delayed neuropathy

por Ding, Qiang, Fang, Sui, Chen, Xueqin, Wang, Youxin, Li, Jian, Tian, Fuyun, Xu, Xiang, Attali, Bernard, Xie, Xin, Gao, Zhaobing
Publicado 2017

Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation

por Wan, Xia, Lu, Yungang, Chen, Xueqin, Xiong, Jian, Zhou, Yuanda, Li, Ping, Xia, Bingqing, Li, Min, Zhu, Michael X., Gao, Zhaobing
Publicado 2013

Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

por Sun, Xian, Zhang, Xiaochuan, Ren, Xiaohong, Sun, Hongyu, Wu, Li, Wang, Caifen, Ye, Xiaohui, York, Peter, Gao, Zhaobing, Jiang, Hualiang, Zhang, Jiwen, Yin, Xianzhen
Publicado 2021

Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies

por Guo, Liang, Mao, Qionglei, He, Ji, Liu, Xiaoling, Piao, Xuejiao, Luo, Li, Hao, Xiaoxu, Yu, Hanzhi, Song, Qiang, Xiao, Bailong, Fan, Dongsheng, Gao, Zhaobing, Jia, Yichang
Publicado 2023

Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation

por Guo, Ren, Jia, Xiaohui, Ding, Zhenbin, Wang, Gang, Jiang, Mengmeng, Li, Bing, Chen, Shanshan, Xia, Bingqing, Zhang, Qing, Liu, Jian, Zheng, Ruting, Gao, Zhaobing, Xie, Xin
Publicado 2022

Ligand activation mechanisms of human KCNQ2 channel

por Ma, Demin, Zheng, Yueming, Li, Xiaoxiao, Zhou, Xiaoyu, Yang, Zhenni, Zhang, Yan, Wang, Long, Zhang, Wenbo, Fang, Jiajia, Zhao, Guohua, Hou, Panpan, Nan, Fajun, Yang, Wei, Su, Nannan, Gao, Zhaobing, Guo, Jiangtao
Publicado 2023

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

por Xia, Bingqing, Pan, Xiaoyan, Luo, Rong-Hua, Shen, Xurui, Li, Shuangqu, Wang, Yi, Zuo, Xiaoli, Wu, Yan, Guo, Yingqi, Xiao, Gengfu, Li, Qiguang, Long, Xin-Yan, He, Xiao-Yan, Zheng, Hong-Yi, Lu, Ying, Pang, Wei, Zheng, Yong-Tang, Li, Jia, Zhang, Lei-Ke, Gao, Zhaobing
Publicado 2023

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

por Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, Feng-Liang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, Hai-Lin, Yu, Dan-Dan, Li, Ming-Hua, Feng, Xiao-Li, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, Yong-Tang, Zhang, Lei-Ke, Shen, Jingshan, Li, Jia, Gao, Zhaobing
Publicado 2021