From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis

por Nozal, Vanesa, García‐Rubia, Alfonso, Cuevas, Eva P., Pérez, Concepción, Tosat‐Bitrián, Carlota, Bartolomé, Fernando, Carro, Eva, Ramírez, David, Palomo, Valle, Martínez, Ana
Publicado 2021

The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

por Cogram, Patricia, Fernández-Beltrán, Luis C., Casarejos, María José, Sánchez-Yepes, Sonia, Rodríguez-Martín, Eulalia, García-Rubia, Alfonso, Sánchez-Barrena, María José, Gil, Carmen, Martínez, Ana, Mansilla, Alicia
Publicado 2022

Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses

por Lasala, Fátima, García-Rubia, Alfonso, Requena, Carlos, Galindo, Inmaculada, Cuesta-Geijo, Miguel Angel, García-Dorival, Isabel, Bueno, Paula, Labiod, Nuria, Luczkowiak, Joanna, Martinez, Ana, Campillo, Nuria E., Alonso, Covadonga, Delgado, Rafael, Gil, Carmen
Publicado 2021

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

por Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Publicado 2020

N′-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile

por Garcia-Rubia, Alfonso, Lasala, Fátima, Ginex, Tiziana, Morales-Tenorio, Marcos, Olal, Catherine, Heung, Michelle, Oquist, Paola, Galindo, Inmaculada, Cuesta-Geijo, Miguel Ángel, Casasnovas, José M., Campillo, Nuria E., Canales, Ángeles, Alonso, Covadonga, Martínez, Ana, Muñoz-Fontela, César, Delgado, Rafael, Gil, Carmen
Publicado 2023

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

por Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Publicado 2019