A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element

por van Arensbergen, Joris, Dussaud, Sebastien, Pardanaud-Glavieux, Corinne, García-Hurtado, Javier, Sauty, Claire, Guerci, Aline, Ferrer, Jorge, Ravassard, Philippe
Publicado 2017

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

por Miguel-Escalada, Irene, Maestro, Miguel Ángel, Balboa, Diego, Elek, Anamaria, Bernal, Aina, Bernardo, Edgar, Grau, Vanessa, García-Hurtado, Javier, Sebé-Pedrós, Arnau, Ferrer, Jorge
Publicado 2022

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis

por Rovira, Meritxell, Atla, Goutham, Maestro, Miguel Angel, Grau, Vane, García-Hurtado, Javier, Maqueda, Maria, Mosquera, Jose Luis, Yamada, Yasuhiro, Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge
Publicado 2021

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

por Akerman, Ildem, Maestro, Miguel Angel, De Franco, Elisa, Grau, Vanessa, Flanagan, Sarah, García-Hurtado, Javier, Mittler, Gerhard, Ravassard, Philippe, Piemonti, Lorenzo, Ellard, Sian, Hattersley, Andrew T., Ferrer, Jorge
Publicado 2021

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

por Beucher, Anthony, Miguel-Escalada, Irene, Balboa, Diego, De Vas, Matías G., Maestro, Miguel Angel, Garcia-Hurtado, Javier, Bernal, Aina, Gonzalez-Franco, Roser, Vargiu, Pierfrancesco, Heyn, Holger, Ravassard, Philippe, Ortega, Sagrario, Ferrer, Jorge
Publicado 2022

Genetic regulation of RNA splicing in human pancreatic islets

por Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J. M., Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B., Gloyn, Anna L., Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge
Publicado 2022

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

por Akerman, Ildem, Tu, Zhidong, Beucher, Anthony, Rolando, Delphine M.Y., Sauty-Colace, Claire, Benazra, Marion, Nakic, Nikolina, Yang, Jialiang, Wang, Huan, Pasquali, Lorenzo, Moran, Ignasi, Garcia-Hurtado, Javier, Castro, Natalia, Gonzalez-Franco, Roser, Stewart, Andrew F., Bonner, Caroline, Piemonti, Lorenzo, Berney, Thierry, Groop, Leif, Kerr-Conte, Julie, Pattou, Francois, Argmann, Carmen, Schadt, Eric, Ravassard, Philippe, Ferrer, Jorge
Publicado 2017

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants

por Pasquali, Lorenzo, Gaulton, Kyle J., Rodríguez-Seguí, Santiago A., Mularoni, Loris, Miguel-Escalada, Irene, Akerman, İldem, Tena, Juan J., Morán, Ignasi, Gómez-Marín, Carlos, van de Bunt, Martijn, Ponsa-Cobas, Joan, Castro, Natalia, Nammo, Takao, Cebola, Inês, García-Hurtado, Javier, Maestro, Miguel Angel, Pattou, François, Piemonti, Lorenzo, Berney, Thierry, Gloyn, Anna L., Ravassard, Philippe, Skarmeta, José Luis Gómez, Müller, Ferenc, McCarthy, Mark I., Ferrer, Jorge
Publicado 2014