Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

por Garcia-Marcos, Mikel
Publicado 2021

DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction

por Marivin, Arthur, Garcia-Marcos, Mikel
Publicado 2019

DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes

por Marivin, Arthur, Ho, Rachel Xi-Yeen, Garcia-Marcos, Mikel
Publicado 2022

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP

por Luebbers, Alex, Zhou, Myles, Eyles, Stephen J, Garcia-Marcos, Mikel
Publicado 2023

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

por Garcia-Marcos, Mikel, Ear, Jason, Farquhar, Marilyn G., Ghosh, Pradipta
Publicado 2011

Activation of Gαi3 triggers cell migration via regulation of GIV

por Ghosh, Pradipta, Garcia-Marcos, Mikel, Bornheimer, Scott J., Farquhar, Marilyn G.
Publicado 2008

Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin

por Leyme, Anthony, Marivin, Arthur, Perez-Gutierrez, Lorena, Nguyen, Lien T., Garcia-Marcos, Mikel
Publicado 2015

Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

por Garcia-Marcos, Mikel, Parag-Sharma, Kshitij, Marivin, Arthur, Maziarz, Marcin, Luebbers, Alex, Nguyen, Lien T
Publicado 2020

Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin)

por Beas, Anthony O., Taupin, Vanessa, Teodorof, Carmen, Nguyen, Lien T., Garcia-Marcos, Mikel, Farquhar, Marilyn G.
Publicado 2012

Pharmacological evidence for the stimulation of NADPH oxidase by P2X(7) receptors in mouse submandibular glands

por Seil, Michèle, Fontanils, Unai, Etxebarria, Irantzu Gorrono, Pochet, Stéphanie, Garcia-Marcos, Mikel, Marino, Aida, Dehaye, Jean-Paul
Publicado 2008

Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling

por Maziarz, Marcin, Federico, Anthony, Zhao, Jingyi, Dujmusic, Lorena, Zhao, Zhiming, Monti, Stefano, Varelas, Xaralabos, Garcia-Marcos, Mikel
Publicado 2021

GPCR-independent activation of G proteins promotes apical cell constriction in vivo

por Marivin, Arthur, Morozova, Veronika, Walawalkar, Isha, Leyme, Anthony, Kretov, Dmitry A., Cifuentes, Daniel, Dominguez, Isabel, Garcia-Marcos, Mikel
Publicado 2019

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin

por Lin, Changsheng, Ear, Jason, Midde, Krishna, Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Garcia-Marcos, Mikel, Kufareva, Irina, Abagyan, Ruben, Ghosh, Pradipta
Publicado 2014

The Gαi-GIV binding interface is a druggable protein-protein interaction

por DiGiacomo, Vincent, de Opakua, Alain Ibáñez, Papakonstantinou, Maria P., Nguyen, Lien T., Merino, Nekane, Blanco-Canosa, Juan B., Blanco, Francisco J., Garcia-Marcos, Mikel
Publicado 2017

Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation

por Coleman, Brantley D., Marivin, Arthur, Parag-Sharma, Kshitij, DiGiacomo, Vincent, Kim, Seongseop, Pepper, Judy S., Casler, Jason, Nguyen, Lien T., Koelle, Michael R., Garcia-Marcos, Mikel
Publicado 2016

Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer

por Zhao, Jingyi, DiGiacomo, Vincent, Ferreras-Gutierrez, Mariola, Dastjerdi, Shiva, Ibáñez de Opakua, Alain, Park, Jong-Chan, Luebbers, Alex, Chen, Qingyan, Beeler, Aaron, Blanco, Francisco J., Garcia-Marcos, Mikel
Publicado 2023

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

por Ghosh, Pradipta, Beas, Anthony O., Bornheimer, Scott J., Garcia-Marcos, Mikel, Forry, Erin P., Johannson, Carola, Ear, Jason, Jung, Barbara H., Cabrera, Betty, Carethers, John M., Farquhar, Marilyn G.
Publicado 2010

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

por Aznar, Nicolas, Midde, Krishna K, Dunkel, Ying, Lopez-Sanchez, Inmaculada, Pavlova, Yelena, Marivin, Arthur, Barbazán, Jorge, Murray, Fiona, Nitsche, Ulrich, Janssen, Klaus-Peter, Willert, Karl, Goel, Ajay, Abal, Miguel, Garcia-Marcos, Mikel, Ghosh, Pradipta
Publicado 2015

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

por de Opakua, Alain Ibáñez, Parag-Sharma, Kshitij, DiGiacomo, Vincent, Merino, Nekane, Leyme, Anthony, Marivin, Arthur, Villate, Maider, Nguyen, Lien T., de la Cruz-Morcillo, Miguel Angel, Blanco-Canosa, Juan B., Ramachandran, Sekar, Baillie, George S., Cerione, Richard A., Blanco, Francisco J., Garcia-Marcos, Mikel
Publicado 2017