Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

por Flores-Romero, Hector, Garcia-Porras, Miguel, Basañez, Gorka
Publicado 2017

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL

por Flores-Romero, Hector, Landeta, Olatz, Ugarte-Uribe, Begoña, Cosentino, Katia, García-Porras, Miguel, García-Sáez, Ana J., Basañez, Gorka
Publicado 2018

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface

por Rujas, Edurne, Caaveiro, Jose M. M., Partida-Hanon, Angélica, Gulzar, Naveed, Morante, Koldo, Apellániz, Beatriz, García-Porras, Miguel, Bruix, Marta, Tsumoto, Kouhei, Scott, Jamie K., Jiménez, M. Ángeles, Nieva, José L.
Publicado 2016

Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8

por Insausti, Sara, Garcia-Porras, Miguel, Torralba, Johana, Morillo, Izaskun, Ramos-Caballero, Ander, de la Arada, Igor, Apellaniz, Beatriz, Caaveiro, Jose M. M., Carravilla, Pablo, Eggeling, Christian, Rujas, Edurne, Nieva, Jose L.
Publicado 2022

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

por Rujas, Edurne, Leaman, Daniel P., Insausti, Sara, Carravilla, Pablo, García-Porras, Miguel, Largo, Eneko, Morillo, Izaskun, Sánchez-Eugenia, Rubén, Zhang, Lei, Cui, Hong, Iloro, Ibon, Elortza, Félix, Julien, Jean-Philippe, Eggeling, Christian, Zwick, Michael B., Caaveiro, Jose M.M., Nieva, José L.
Publicado 2021

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments

por Rujas, Edurne, Insausti, Sara, Leaman, Daniel P., Carravilla, Pablo, González-Resines, Saul, Monceaux, Valérie, Sánchez-Eugenia, Rubén, García-Porras, Miguel, Iloro, Ibon, Zhang, Lei, Elortza, Félix, Julien, Jean-Philippe, Saéz-Cirión, Asier, Zwick, Michael B., Eggeling, Christian, Ojida, Akio, Domene, Carmen, Caaveiro, Jose M.M., Nieva, José L.
Publicado 2020