The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

por Feigenbutz, Monika, Garland, William, Turner, Martin, Mitchell, Phil
Publicado 2013

Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6

por Garland, William, Feigenbutz, Monika, Turner, Martin, Mitchell, Phil
Publicado 2013

Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

por Gerlach, Piotr, Garland, William, Lingaraju, Mahesh, Salerno-Kochan, Anna, Bonneau, Fabien, Basquin, Jérôme, Jensen, Torben Heick, Conti, Elena
Publicado 2022

Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

por Garland, William, Müller, Iris, Wu, Mengjun, Schmid, Manfred, Imamura, Katsutoshi, Rib, Leonor, Sandelin, Albin, Helin, Kristian, Jensen, Torben Heick
Publicado 2022

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

por Garland, William, Comet, Itys, Wu, Mengjun, Radzisheuskaya, Aliaksandra, Rib, Leonor, Vitting-Seerup, Kristoffer, Lloret-Llinares, Marta, Sandelin, Albin, Helin, Kristian, Jensen, Torben Heick
Publicado 2019

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay

por Silla, Toomas, Schmid, Manfred, Dou, Yuhui, Garland, William, Milek, Miha, Imami, Koshi, Johnsen, Dennis, Polak, Patrik, Andersen, Jens S, Selbach, Matthias, Landthaler, Markus, Jensen, Torben Heick
Publicado 2020

Anti-tumor effects of an ID antagonist with no observed acquired resistance

por Wojnarowicz, Paulina M., Escolano, Marta Garcia, Huang, Yun-Han, Desai, Bina, Chin, Yvette, Shah, Riddhi, Xu, Sijia, Yadav, Saurabh, Yaklichkin, Sergey, Ouerfelli, Ouathek, Soni, Rajesh Kumar, Philip, John, Montrose, David C., Healey, John H., Rajasekhar, Vinagolu K., Garland, William A., Ratiu, Jeremy, Zhuang, Yuan, Norton, Larry, Rosen, Neal, Hendrickson, Ronald C., Zhou, Xi Kathy, Iavarone, Antonio, Massague, Joan, Dannenberg, Andrew J., Lasorella, Anna, Benezra, Robert
Publicado 2021

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

por Wojnarowicz, Paulina M., Silva, Raquel Lima e, Ohnaka, Masayuki, Lee, Sang Bae, Chin, Yvette, Kulukian, Anita, Chang, Sung-Hee, Desai, Bina, Escolano, Marta Garcia, Shah, Riddhi, Garcia-Cao, Marta, Xu, Sijia, Kadam, Rashmi, Goldgur, Yehuda, Miller, Meredith A., Ouerfelli, Ouathek, Yang, Guangli, Arakawa, Tsutomu, Albanese, Steven K., Garland, William A., Stoller, Glenn, Chaudhary, Jaideep, Norton, Larry, Soni, Rajesh Kumar, Philip, John, Hendrickson, Ronald C., Iavarone, Antonio, Dannenberg, Andrew J., Chodera, John D., Pavletich, Nikola, Lasorella, Anna, Campochiaro, Peter A., Benezra, Robert
Publicado 2019