The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response()

por Garnett, Mathew J, McDermott, Ultan
Publicado 2014

High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

por Williams, Steven P., Barthorpe, Andrew S., Lightfoot, Howard, Garnett, Mathew J., McDermott, Ultan
Publicado 2017

Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer

por Williams, Steven P., Barthorpe, Andrew S., Lightfoot, Howard, Garnett, Mathew J., McDermott, Ultan
Publicado 2018

Inferred Ancestral Origin of Cancer Cell Lines Associates with Differential Drug Response

por Nguyen, Phong B. H., Ohnmacht, Alexander J., Sharifli, Samir, Garnett, Mathew J., Menden, Michael P.
Publicado 2021

Use of preclinical models for malignant pleural mesothelioma

por Shamseddin, Marie, Obacz, Joanna, Garnett, Mathew J, Rintoul, Robert Campbell, Francies, Hayley Elizabeth, Marciniak, Stefan John
Publicado 2021

GDSCTools for mining pharmacogenomic interactions in cancer

por Cokelaer, Thomas, Chen, Elisabeth, Iorio, Francesco, Menden, Michael P, Lightfoot, Howard, Saez-Rodriguez, Julio, Garnett, Mathew J
Publicado 2018

Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

por Eduati, Federica, Jaaks, Patricia, Wappler, Jessica, Cramer, Thorsten, Merten, Christoph A, Garnett, Mathew J, Saez‐Rodriguez, Julio
Publicado 2020

CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens

por Vinceti, Alessandro, Karakoc, Emre, Pacini, Clare, Perron, Umberto, De Lucia, Riccardo Roberto, Garnett, Mathew J., Iorio, Francesco
Publicado 2021

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

por Garnett, Mathew J., Mansfeld, Jörg, Godwin, Colin, Matsusaka, Takahiro, Wu, Jiahua, Russell, Paul, Pines, Jonathon, Venkitaraman, Ashok R.
Publicado 2009

A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions

por Iorio, Francesco, Shrestha, Roshan L., Levin, Nicolas, Boilot, Viviane, Garnett, Mathew J., Saez-Rodriguez, Julio, Draviam, Viji M.
Publicado 2015

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen

por Lynch, James T., McEwen, Robert, Crafter, Claire, McDermott, Ultan, Garnett, Mathew J., Barry, Simon T., Davies, Barry R.
Publicado 2016

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy

por Knijnenburg, Theo A., Klau, Gunnar W., Iorio, Francesco, Garnett, Mathew J., McDermott, Ultan, Shmulevich, Ilya, Wessels, Lodewyk F. A.
Publicado 2016

Perturbation-response genes reveal signaling footprints in cancer gene expression

por Schubert, Michael, Klinger, Bertram, Klünemann, Martina, Sieber, Anja, Uhlitz, Florian, Sauer, Sascha, Garnett, Mathew J., Blüthgen, Nils, Saez-Rodriguez, Julio
Publicado 2018

Cell Model Passports—a hub for clinical, genetic and functional datasets of preclinical cancer models

por van der Meer, Dieudonne, Barthorpe, Syd, Yang, Wanjuan, Lightfoot, Howard, Hall, Caitlin, Gilbert, James, Francies, Hayley E, Garnett, Mathew J
Publicado 2019

RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status

por Dorard, Coralie, Madry, Claire, Buhard, Olivier, Toifl, Stefanie, Didusch, Sebastian, Ratovomanana, Toky, Letourneur, Quentin, Dolznig, Helmut, Garnett, Mathew J., Duval, Alex, Baccarini, Manuela
Publicado 2023

Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

por Gonçalves, Emanuel, Behan, Fiona M., Louzada, Sandra, Arnol, Damien, Stronach, Euan A., Yang, Fengtang, Yusa, Kosuke, Stegle, Oliver, Iorio, Francesco, Garnett, Mathew J.
Publicado 2019

Itraconazole targets cell cycle heterogeneity in colorectal cancer

por Buczacki, Simon J.A., Popova, Semiramis, Biggs, Emma, Koukorava, Chrysa, Buzzelli, Jon, Vermeulen, Louis, Hazelwood, Lee, Francies, Hayley, Garnett, Mathew J., Winton, Douglas J.
Publicado 2018

The germline genetic component of drug sensitivity in cancer cell lines

por Menden, Michael P., Casale, Francesco Paolo, Stephan, Johannes, Bignell, Graham R., Iorio, Francesco, McDermott, Ultan, Garnett, Mathew J., Saez-Rodriguez, Julio, Stegle, Oliver
Publicado 2018

A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

por Wang, Dennis, Hensman, James, Kutkaite, Ginte, Toh, Tzen S, Galhoz, Ana, Dry, Jonathan R, Saez-Rodriguez, Julio, Garnett, Mathew J, Menden, Michael P, Dondelinger, Frank
Publicado 2020

Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets

por Dwane, Lisa, Behan, Fiona M, Gonçalves, Emanuel, Lightfoot, Howard, Yang, Wanjuan, van der Meer, Dieudonne, Shepherd, Rebecca, Pignatelli, Miguel, Iorio, Francesco, Garnett, Mathew J
Publicado 2020