Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production

por Gasset, Arnau, Garcia-Ortega, Xavier, Garrigós-Martínez, Javier, Valero, Francisco, Montesinos-Seguí, José Luis
Publicado 2022

Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) P(AOX1)-driven recombinant producer strains with diff...

por Garrigós-Martínez, Javier, Nieto-Taype, Miguel Angel, Gasset-Franch, Arnau, Montesinos-Seguí, José Luis, Garcia-Ortega, Xavier, Valero, Francisco
Publicado 2019

Rationale‐based selection of optimal operating strategies and gene dosage impact on recombinant protein production in Komagataella phaffii (Pichia pastoris)

por Nieto‐Taype, Miguel Angel, Garrigós‐Martínez, Javier, Sánchez‐Farrando, Marc, Valero, Francisco, Garcia‐Ortega, Xavier, Montesinos‐Seguí, José Luis
Publicado 2019

Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

por Garrigós-Martínez, Javier, Weninger, Astrid, Montesinos-Seguí, José Luis, Schmid, Christian, Valero, Francisco, Rinnofner, Claudia, Glieder, Anton, Garcia-Ortega, Xavier
Publicado 2021

Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris

por Garrigós-Martínez, Javier, Vuoristo, Kiira, Nieto-Taype, Miguel Angel, Tähtiharju, Juha, Uusitalo, Jaana, Tukiainen, Pauliina, Schmid, Christian, Tolstorukov, Ilya, Madden, Knut, Penttilä, Merja, Montesinos-Seguí, José Luis, Valero, Francisco, Glieder, Anton, Garcia-Ortega, Xavier
Publicado 2021