The Ups and Downs of Metabolism during the Lifespan of a T Cell

por Balyan, Renu, Gautam, Namrata, Gascoigne, Nicholas R.J.
Publicado 2020

Generation of gene-of-interest double allele knockout clones in primary human T cells by CRISPR

por Wu, Ling, Tan, Jia Chi, Gascoigne, Nicholas R.J.
Publicado 2023

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

por Yachi, Pia P., Lotz, Carina, Ampudia, Jeanette, Gascoigne, Nicholas R.J.
Publicado 2007

Themis sets the signal threshold for positive and negative selection in T-cell development

por Fu, Guo, Casas, Javier, Rigaud, Stephanie, Rybakin, Vasily, Lambolez, Florence, Brzostek, Joanna, Hoerter, John A.H., Paster, Wolfgang, Acuto, Oreste, Cheroutre, Hilde, Sauer, Karsten, Gascoigne, Nicholas R.J.
Publicado 2013

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor

por Casas, Javier, Brzostek, Joanna, Zarnitsyna, Veronika I., Hong, Jin-sung, Wei, Qianru, Hoerter, John A.H., Fu, Guo, Ampudia, Jeanette, Zamoyska, Rose, Zhu, Cheng, Gascoigne, Nicholas R.J.
Publicado 2014

Hybrid structural modeling of alloantibody binding to human leukocyte antigen with rapid and reproducible cross-linking mass spectrometry

por Ser, Zheng, Gu, Yue, Yap, Jiawei, Lim, Yan Ting, Wang, Shi Mei, Hamidinia, Maryam, Murali, Tanusya Murali, Kumar, Ragini, Gascoigne, Nicholas RJ., MacAry, Paul A., Sobota, Radoslaw M.
Publicado 2023

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

por Hoerter, John A.H., Brzostek, Joanna, Artyomov, Maxim N., Abel, Steven M., Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M., Chakraborty, Arup K., Gould, Keith G., Gascoigne, Nicholas R.J.
Publicado 2013

Themis controls T cell activation, effector functions, and metabolism of peripheral CD8(+) T cells

por Gautam, Namrata, Wojciech, Lukasz, Yap, Jiawei, Chua, Yen Leong, Ding, Eyan MW, Sim, Don CN, Tan, Alrina SM, Ahl, Patricia J, Prasad, Mukul, Tung, Desmond WH, Connolly, John E, Adriani, Giulia, Brzostek, Joanna, Gascoigne, Nicholas RJ
Publicado 2023

A THEMIS:SHP1 complex promotes T-cell survival

por Paster, Wolfgang, Bruger, Annika M, Katsch, Kristin, Grégoire, Claude, Roncagalli, Romain, Fu, Guo, Gascoigne, Nicholas RJ, Nika, Konstantina, Cohnen, Andre, Feller, Stephan M, Simister, Philip C, Molder, Kelly C, Cordoba, Shaun-Paul, Dushek, Omer, Malissen, Bernard, Acuto, Oreste
Publicado 2015

A tryptophan metabolite made by a gut microbiome eukaryote induces pro‐inflammatory T cells

por Wojciech, Lukasz, Png, Chin Wen, Koh, Eileen Y, Kioh, Dorinda Yan Qin, Deng, Lei, Wang, Ziteng, Wu, Liang‐zhe, Hamidinia, Maryam, Tung, Desmond WH, Zhang, Wei, Pettersson, Sven, Chan, Eric Chun Yong, Zhang, Yongliang, Tan, Kevin SW, Gascoigne, Nicholas RJ
Publicado 2023

Themis controls thymocyte selection through regulation of T cell receptor-mediated signaling

por Fu, Guo, Vallée, Sébastien, Rybakin, Vasily, McGuire, Marielena V., Ampudia, Jeanette, Brockmeyer, Claudia, Salek, Mogjiborahman, Fallen, Paul R., Hoerter, John A.H., Munshi, Anil, Huang, Yina H., Hu, Jianfang, Fox, Howard S., Sauer, Karsten, Acuto, Oreste, Gascoigne, Nicholas R.J.
Publicado 2009

CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance

por Wu, Ling, Brzostek, Joanna, Sakthi Vale, Previtha Dawn, Wei, Qianru, Koh, Clara K.T., Ong, June Xu Hui, Wu, Liang-zhe, Tan, Jia Chi, Chua, Yen Leong, Yap, Jiawei, Song, Yuan, Tan, Vivian Jia Yi, Tan, Triscilla Y.Y., Lai, Junyun, MacAry, Paul A., Gascoigne, Nicholas R.J.
Publicado 2023