Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR

por Cetin, Ebru, Guclu, Tandac F., Kantarcioglu, Isik, Gaszek, Ilona K., Toprak, Erdal, Atilgan, Ali Rana, Dedeoglu, Burcu, Atilgan, Canan
Publicado 2023

The Antibiotic Efflux Protein TolC Is a Highly Evolvable Target under Colicin E1 or TLS Phage Selection

por Tamer, Yusuf Talha, Gaszek, Ilona, Rodrigues, Marinelle, Coskun, Fatma Sevde, Farid, Michael, Koh, Andrew Y, Russ, William, Toprak, Erdal
Publicado 2021

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

por Tamer, Yusuf Talha, Gaszek, Ilona K, Abdizadeh, Haleh, Batur, Tugce Altinusak, Reynolds, Kimberly A, Atilgan, Ali Rana, Atilgan, Canan, Toprak, Erdal
Publicado 2019

A trimethoprim derivative impedes antibiotic resistance evolution

por Manna, Madhu Sudan, Tamer, Yusuf Talha, Gaszek, Ilona, Poulides, Nicole, Ahmed, Ayesha, Wang, Xiaoyu, Toprak, Furkan C. R., Woodard, DaNae R., Koh, Andrew Y., Williams, Noelle S., Borek, Dominika, Atilgan, Ali Rana, Hulleman, John D., Atilgan, Canan, Tambar, Uttam, Toprak, Erdal
Publicado 2021