Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

por Gatfield, John, Mueller Grandjean, Celia, Sasse, Thomas, Clozel, Martine, Nayler, Oliver
Publicado 2012

Distinct ET(A) Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

por Gatfield, John, Mueller Grandjean, Celia, Bur, Daniel, Bolli, Martin H., Nayler, Oliver
Publicado 2014

Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P(1) Receptor Modulator

por Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat
Publicado 2013

Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP(2) and EP(4) receptors

por Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W. D., Gatfield, John, Peter, Oliver, Nayler, Oliver, Lüthi, Urs
Publicado 2018

GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

por Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John
Publicado 2020