The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses

por Sukumar, Madhusudhanan, Gattinoni, Luca
Publicado 2014

T memory stem cell formation: Caveat mTOR

por Fowler, Daniel H., Gattinoni, Luca
Publicado 2016

International Regensburg Center for Interventional Immunology (RCI) symposium on “Synthetic immunology and environment-adapted redirection of T cells”, 17–18 July, 2019, Regensburg...

por Beckhove, Philipp, Edinger, Matthias, Feuerer, Markus, Gattinoni, Luca, Abken, Hinrich
Publicado 2020

Modulating immunometabolism of tumor specific CD8 T cells to enhance T cell based therapy for cancer

por Sukumar, Madhusudhanan, Liu, Jie, Mehta, Gautam, Gattinoni, Luca, Finkel, Toren, Restifo, Nicholas
Publicado 2014

Mitochondrial activity regulates T cell memory, self renewal and anti tumor function in CD8+ T cells

por Sukumar, Madhusudhanan, Liu, Jie, Crompton, Joseph, Rao, Mahadev, Ji, Yun, Finkel, Toren, Gattinoni, Luca, Restifo, Nicholas
Publicado 2013

The New Old CD8+ T Cells in the Immune Paradox of Pregnancy

por Hardardottir, Lilja, Bazzano, Maria Victoria, Glau, Laura, Gattinoni, Luca, Köninger, Angela, Tolosa, Eva, Solano, Maria Emilia
Publicado 2021

Fas expression in memory CD8+ T cell subsets augments cellular differentiation and effector function

por Yamamoto, Tori, Leonardi, Anthony, Liu, Hui, Wang, Ena, Gattinoni, Luca, Cruz, Anthony, Ouyang, Claudia, Siegel, Richard, Restifo, Nicholas, Klebanoff, Christopher A
Publicado 2015

Induction of an acute vitamin A-deficient state following total body irradiation impairs anti-tumor immunity by altering the homeostasis of pre-cDC derived dendritic cells

por Klebanoff, Christopher A, Spencer, Sean, Roychoudhuri, Rahu, Ji, Yun, Sukumar, Madhu, Muranski, Pawel, Napoli, Joseph L, Gattinoni, Luca, Belkaid, Yasmine, Restifo, Nicholas P
Publicado 2013

Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing

por Ji, Yun, Abrams, Natalie, Zhu, Wei, Salinas, Eddie, Yu, Zhiya, Palmer, Douglas C., Jailwala, Parthav, Franco, Zulmarie, Roychoudhuri, Rahul, Stahlberg, Eric, Gattinoni, Luca, Restifo, Nicholas P.
Publicado 2014

Modulating immunometabolism of tumor specific mouse and human lymphocytes to enhance T cell based therapy for cancer

por Sukumar, Madhusudhanan, Liu, Jie, Patel, Shashank J, Klebanoff, Christopher A, Mehta, Gautam, Roychoudhuri, Rahul, Crompton, Joseph, Clever, David, Gattinoni, Luca, Muranski, Pawel, Finkel, Toren, Restifo, Nicholas
Publicado 2015

Wnt signaling arrests effector T cell differentiation and generates CD8(+) memory stem cells

por Gattinoni, Luca, Zhong, Xiao-Song, Palmer, Douglas C, Ji, Yun, Hinrichs, Christian S, Yu, Zhiya, Wrzesinski, Claudia, Boni, Andrea, Cassard, Lydie, Church, Lindsay, Paulos, Chrystal M, Muranski, Pawel, Restifo, Nicholas P
Publicado 2009

BACH2 represses effector programmes to stabilize Treg-mediated immune homeostasis - a new target in tumor immunotherapy?

por Roychoudhuri, Rahul, Hirahara, Kiyoshi, Mousavi, Kambiz, Clever, David, Bonelli, Michael, Klebanoff, Christopher, Sartorelli, Vittorio, Kanno, Yuka, Gattinoni, Luca, Wang, Ena, Liu, Hui, Marincola, Franco, Kazuhiko, Igarashi, O’Shea, John, Restifo, Nicholas P
Publicado 2013

Ezh2 phosphorylation state determines its capacity to maintain CD8(+) T memory precursors for antitumor immunity

por He, Shan, Liu, Yongnian, Meng, Lijun, Sun, Hongxing, Wang, Ying, Ji, Yun, Purushe, Janaki, Chen, Pan, Li, Changhong, Madzo, Jozef, Issa, Jean-Pierre, Soboloff, Jonathan, Reshef, Ran, Moore, Bethany, Gattinoni, Luca, Zhang, Yi
Publicado 2017

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8(+) T cells

por Gattinoni, Luca, Finkelstein, Steven E., Klebanoff, Christopher A., Antony, Paul A., Palmer, Douglas C., Spiess, Paul J., Hwang, Leroy N., Yu, Zhiya, Wrzesinski, Claudia, Heimann, David M., Surh, Charles D., Rosenberg, Steven A., Restifo, Nicholas P.
Publicado 2005

Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits CD8(+) T cell memory formation

por Ji, Yun, Pos, Zoltan, Rao, Mahadev, Klebanoff, Christopher A., Yu, Zhiya, Sukumar, Madhusudhanan, Reger, Robert N., Palmer, Douglas C., Borman, Zachary A., Muranski, Pawel, Wang, Ena, Schrump, David S., Marincola, Francesco M., Restifo, Nicholas P., Gattinoni, Luca
Publicado 2011

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8(+) effector and memory T cell populations during infection

por Omilusik, Kyla D., Best, J. Adam, Yu, Bingfei, Goossens, Steven, Weidemann, Alexander, Nguyen, Jessica V., Seuntjens, Eve, Stryjewska, Agata, Zweier, Christiane, Roychoudhuri, Rahul, Gattinoni, Luca, Bird, Lynne M., Higashi, Yujiro, Kondoh, Hisato, Huylebroeck, Danny, Haigh, Jody, Goldrath, Ananda W.
Publicado 2015

Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8(+) T cells for adoptive immunotherapy

por Mousset, Charlotte M., Hobo, Willemijn, Ji, Yun, Fredrix, Hanny, De Giorgi, Valeria, Allison, Robert D., Kester, Michel G. D., Falkenburg, J. H. Frederik, Schaap, Nicolaas P. M., Jansen, Joop H., Gattinoni, Luca, Dolstra, Harry, van der Waart, Anniek B.
Publicado 2018

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

por Crompton, Joseph G., Narayanan, Manikandan, Cuddapah, Suresh, Roychoudhuri, Rahul, Ji, Yun, Yang, Wenjing, Patel, Shashank J., Sukumar, Madhusudhanan, Palmer, Douglas C., Peng, Weiqun, Wang, Ena, Marincola, Francesco M., Klebanoff, Christopher A., Zhao, Keji, Tsang, John S., Gattinoni, Luca, Restifo, Nicholas P.
Publicado 2016

A human memory T-cell subset with stem cell-like properties

por Gattinoni, Luca, Lugli, Enrico, Ji, Yun, Pos, Zoltan, Paulos, Chrystal M., Quigley, Máire F., Almeida, Jorge R., Gostick, Emma, Yu, Zhiya, Carpenito, Carmine, Wang, Ena, Douek, Daniel C., Price, David A., June, Carl H., Marincola, Francesco M., Roederer, Mario, Restifo, Nicholas P.
Publicado 2011

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

por Stroncek, David F, Berger, Carolina, Cheever, Martin A, Childs, Richard W, Dudley, Mark E, Flynn, Peter, Gattinoni, Luca, Heath, James R, Kalos, Michael, Marincola, Francesco M, Miller, Jeffrey S, Mostoslavsky, Gustavo, Powell, Daniel J, Rao, Mahendra, Restifo, Nicholas P, Rosenberg, Steven A, O'Shea, John, Melief, Cornelis JM
Publicado 2012