Identification of a Regulatory Variant That Binds FOXA1 and FOXA2 at the CDC123/CAMK1D Type 2 Diabetes GWAS Locus

por Fogarty, Marie P., Cannon, Maren E., Vadlamudi, Swarooparani, Gaulton, Kyle J., Mohlke, Karen L.
Publicado 2014

An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets

por Elgamal, Ruth M., Kudtarkar, Parul, Melton, Rebecca L., Mummey, Hannah M., Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle J.
Publicado 2023

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

por Aylward, Anthony, Okino, Mei-Lin, Benaglio, Paola, Chiou, Joshua, Beebe, Elisha, Padilla, Jose Andres, Diep, Sharlene, Gaulton, Kyle J.
Publicado 2021

An integrated map of cell type-specific gene expression in pancreatic islets

por Elgamal, Ruth M, Kudtarkar, Parul, Melton, Rebecca L, Mummey, Hannah M, Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle J
Publicado 2023

Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

por Reschen, Michael E., Gaulton, Kyle J., Lin, Da, Soilleux, Elizabeth J., Morris, Andrew J., Smyth, Susan S., O'Callaghan, Christopher A.
Publicado 2015

Assessing association between protein truncating variants and quantitative traits

por Rivas, Manuel A., Pirinen, Matti, Neville, Matthew J., Gaulton, Kyle J., Moutsianas, Loukas, Lindgren, Cecilia M., Karpe, Fredrik, McCarthy, Mark I., Donnelly, Peter
Publicado 2013

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

por Fernández-Tajes, Juan, Gaulton, Kyle J., van de Bunt, Martijn, Torres, Jason, Thurner, Matthias, Mahajan, Anubha, Gloyn, Anna L., Lage, Kasper, McCarthy, Mark I.
Publicado 2019

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

por van de Bunt, Martijn, Gaulton, Kyle J., Parts, Leopold, Moran, Ignasi, Johnson, Paul R., Lindgren, Cecilia M., Ferrer, Jorge, Gloyn, Anna L., McCarthy, Mark I.
Publicado 2013

Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

por Benaglio, Paola, Newsome, Jacklyn, Han, Jee Yun, Chiou, Joshua, Aylward, Anthony, Corban, Sierra, Miller, Michael, Okino, Mei-Lin, Kaur, Jaspreet, Preissl, Sebastian, Gorkin, David U., Gaulton, Kyle J.
Publicado 2023

The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease

por Moutsianas, Loukas, Agarwala, Vineeta, Fuchsberger, Christian, Flannick, Jason, Rivas, Manuel A., Gaulton, Kyle J., Albers, Patrick K., McVean, Gil, Boehnke, Michael, Altshuler, David, McCarthy, Mark I.
Publicado 2015

Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal

por Kudtarkar, Parul, Costanzo, Maria C., Sun, Ying, Jang, Dongkeun, Koesterer, Ryan, Mychaleckyj, Josyf C., Nayak, Uma, Onengut-Gumuscu, Suna, Rich, Stephen S., Flannick, Jason A., Gaulton, Kyle J., Burtt, Noël P.
Publicado 2023

Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal

por Kudtarkar, Parul, Costanzo, Maria C., Sun, Ying, Jang, Dongkeun, Koesterer, Ryan, Mychaleckyj, Josyf C, Nayak, Uma, Onengut-Gumuscu, Suna, Rich, Stephen S, Flannick, Jason A, Gaulton, Kyle J, Burtt, Noël P
Publicado 2023

Common DNA sequence variation influences 3-dimensional conformation of the human genome

por Gorkin, David U., Qiu, Yunjiang, Hu, Ming, Fletez-Brant, Kipper, Liu, Tristin, Schmitt, Anthony D., Noor, Amina, Chiou, Joshua, Gaulton, Kyle J., Sebat, Jonathan, Li, Yun, Hansen, Kasper D., Ren, Bing
Publicado 2019

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

por Geusz, Ryan J, Wang, Allen, Chiou, Joshua, Lancman, Joseph J, Wetton, Nichole, Kefalopoulou, Samy, Wang, Jinzhao, Qiu, Yunjiang, Yan, Jian, Aylward, Anthony, Ren, Bing, Dong, P Duc Si, Gaulton, Kyle J, Sander, Maike
Publicado 2021

A map of open chromatin in human pancreatic islets

por Gaulton, Kyle J., Nammo, Takao, Pasquali, Lorenzo, Simon, Jeremy M., Giresi, Paul G., Fogarty, Marie P., Panhuis, Tami M., Mieczkowski, Piotr, Secchi, Antonio, Bosco, Domenico, Berney, Thierry, Montanya, Eduard, Mohlke, Karen L., Lieb, Jason D., Ferrer, Jorge
Publicado 2010

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

por Geusz, Ryan J., Wang, Allen, Lam, Dieter K., Vinckier, Nicholas K., Alysandratos, Konstantinos-Dionysios, Roberts, David A., Wang, Jinzhao, Kefalopoulou, Samy, Ramirez, Araceli, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J., Ren, Bing, Kotton, Darrell N., Sander, Maike
Publicado 2021

The long noncoding RNA ROCKI regulates inflammatory gene expression

por Zhang, Qiong, Chao, Ti‐Chun, Patil, Veena S, Qin, Yue, Tiwari, Shashi Kant, Chiou, Joshua, Dobin, Alexander, Tsai, Chih‐Ming, Li, Zhonghan, Dang, Jason, Gupta, Shagun, Urdahl, Kevin, Nizet, Victor, Gingeras, Thomas R, Gaulton, Kyle J, Rana, Tariq M
Publicado 2019

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

por van de Bunt, Martijn, Manning Fox, Jocelyn E., Dai, Xiaoqing, Barrett, Amy, Grey, Caleb, Li, Lei, Bennett, Amanda J., Johnson, Paul R., Rajotte, Raymond V., Gaulton, Kyle J., Dermitzakis, Emmanouil T., MacDonald, Patrick E., McCarthy, Mark I., Gloyn, Anna L.
Publicado 2015

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

por Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I
Publicado 2018

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

por Smith, Kirk, Deutsch, Aaron J., McGrail, Carolyn, Kim, Hyunkyung, Hsu, Sarah, Mandla, Ravi, Schroeder, Philip H., Westerman, Kenneth E., Szczerbinski, Lukasz, Majarian, Timothy D., Kaur, Varinderpal, Williamson, Alice, Claussnitzer, Melina, Florez, Jose C., Manning, Alisa K., Mercader, Josep M., Gaulton, Kyle J., Udler, Miriam S.
Publicado 2023