Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor

por Gaus, Hans, Miller, Colton M., Seth, Punit P., Harris, Edward N.
Publicado 2018

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

por Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P
Publicado 2019

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

por Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Publicado 2020

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

por Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Publicado 2017

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2015

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2017

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado 2014

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

por Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Publicado 2019

Elucidation of the Biotransformation Pathways of a Galnac(3)-conjugated Antisense Oligonucleotide in Rats and Monkeys

por Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang, Yanfeng
Publicado 2016

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates

por Slingsby, Martina H. Lundberg, Vijey, Prakrith, Tsai, I-Ting, Roweth, Harvey, Couldwell, Genevieve, Wilkie, Adrian R., Gaus, Hans, Goolsby, Jazana M., Okazaki, Ross, Terkovich, Brooke E., Semple, John W., Thon, Jonathan N., Henry, Scott P., Narayanan, Padmakumar, Italiano, Joseph E.
Publicado 2021

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

por Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Publicado 2019

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

por Prakash, Thazha P., Graham, Mark J., Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F., Riney, Stan, Booten, Sheri L., Murray, Susan F., Gaus, Hans, Crosby, Jeff, Lima, Walt F., Guo, Shuling, Monia, Brett P., Swayze, Eric E., Seth, Punit P.
Publicado 2014

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

por Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P
Publicado 2019