Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid

por Vobruba, Simon, Kadlcik, Stanislav, Gazak, Radek, Janata, Jiri
Publicado 2017

C-C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation

por Kamenik, Zdenek, Gazak, Radek, Kadlcik, Stanislav, Steiningerova, Lucie, Rynd, Vit, Janata, Jiri
Publicado 2018

Anti-Cancer Efficacy of Silybin Derivatives - A Structure-Activity Relationship

por Agarwal, Chapla, Wadhwa, Ritambhara, Deep, Gagan, Biedermann, David, Gažák, Radek, Křen, Vladimír, Agarwal, Rajesh
Publicado 2013

Sequence analysis of porothramycin biosynthetic gene cluster

por Najmanova, Lucie, Ulanova, Dana, Jelinkova, Marketa, Kamenik, Zdenek, Kettnerova, Eliska, Koberska, Marketa, Gazak, Radek, Radojevic, Bojana, Janata, Jiri
Publicado 2014

New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C–C Bond?

por Jiraskova, Petra, Gazak, Radek, Kamenik, Zdenek, Steiningerova, Lucie, Najmanova, Lucie, Kadlcik, Stanislav, Novotna, Jitka, Kuzma, Marek, Janata, Jiri
Publicado 2016

Deacetylation of mycothiol-derived ‘waste product’ triggers the last biosynthetic steps of lincosamide antibiotics

por Kamenik, Zdenek, Kadlcik, Stanislav, Radojevic, Bojana, Jiraskova, Petra, Kuzma, Marek, Gazak, Radek, Najmanova, Lucie, Kopecky, Jan, Janata, Jiri
Publicado 2016

Adaptation of an L-Proline Adenylation Domain to Use 4-Propyl-L-Proline in the Evolution of Lincosamide Biosynthesis

por Kadlčík, Stanislav, Kučera, Tomáš, Chalupská, Dominika, Gažák, Radek, Koběrská, Markéta, Ulanová, Dana, Kopecký, Jan, Kutejová, Eva, Najmanová, Lucie, Janata, Jiří
Publicado 2013

cis–trans Isomerization of silybins A and B

por Novotná, Michaela, Gažák, Radek, Biedermann, David, Di Meo, Florent, Marhol, Petr, Kuzma, Marek, Bednárová, Lucie, Fuksová, Kateřina, Trouillas, Patrick, Křen, Vladimír
Publicado 2014

Lincosamide Synthetase—A Unique Condensation System Combining Elements of Nonribosomal Peptide Synthetase and Mycothiol Metabolism

por Janata, Jiri, Kadlcik, Stanislav, Koberska, Marketa, Ulanova, Dana, Kamenik, Zdenek, Novak, Petr, Kopecky, Jan, Novotna, Jitka, Radojevic, Bojana, Plhackova, Kamila, Gazak, Radek, Najmanova, Lucie
Publicado 2015