Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?

por Maul, Robert W., Gearhart, Patricia J.
Publicado 2009

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination

por Martomo, Stella A., Yang, William W., Gearhart, Patricia J.
Publicado 2004

Exceptional Antibodies Produced by Successive Immunizations

por Gearhart, Patricia J., Castiblanco, Diana P., Russell Knode, Lisa M.
Publicado 2015

Antibodies in action: the role of humoral immunity in the fight against atherosclerosis

por Taylor, Joshua A., Hutchinson, Mark A., Gearhart, Patricia J., Maul, Robert W.
Publicado 2022

Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions

por Zeng, Xianmin, Negrete, George A., Kasmer, Cynthia, Yang, William W., Gearhart, Patricia J.
Publicado 2004

Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen

por Castiblanco, Diana P., Maul, Robert W., Russell Knode, Lisa M., Gearhart, Patricia J.
Publicado 2017

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

por Rajagopal, Deepa, Maul, Robert W., Ghosh, Amalendu, Chakraborty, Tirtha, Khamlichi, Ahmed Amine, Sen, Ranjan, Gearhart, Patricia J.
Publicado 2009

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions

por Saribasak, Huseyin, Maul, Robert W., Cao, Zheng, Yang, William W., Schenten, Dominik, Kracker, Sven, Gearhart, Patricia J.
Publicado 2012

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

por Phung, Quy H., Winter, David B., Cranston, Aaron, Tarone, Robert E., Bohr, Vilhelm A., Fishel, Richard, Gearhart, Patricia J.
Publicado 1998

129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

por McDonald, John P., Frank, Ekaterina G., Plosky, Brian S., Rogozin, Igor B., Masutani, Chikahide, Hanaoka, Fumio, Woodgate, Roger, Gearhart, Patricia J.
Publicado 2003

MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

por Wilson, Teresa M., Vaisman, Alexandra, Martomo, Stella A., Sullivan, Patsa, Lan, Li, Hanaoka, Fumio, Yasui, Akira, Woodgate, Roger, Gearhart, Patricia J.
Publicado 2005

Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells

por Maul, Robert W., Cao, Zheng, Venkataraman, Lakshmi, Giorgetti, Carol A., Press, Joan L., Denizot, Yves, Du, Hansen, Sen, Ranjan, Gearhart, Patricia J.
Publicado 2014

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes

por Saribasak, Huseyin, Maul, Robert W., Cao, Zheng, McClure, Rhonda L., Yang, William, McNeill, Daniel R., Wilson, David M., Gearhart, Patricia J.
Publicado 2011

Transcriptome and IgH Repertoire Analyses Show That CD11c(hi) B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

por Maul, Robert W., Catalina, Michelle D., Kumar, Varsha, Bachali, Prathyusha, Grammer, Amrie C., Wang, Shu, Yang, William, Hasni, Sarfaraz, Ettinger, Rachel, Lipsky, Peter E., Gearhart, Patricia J.
Publicado 2021

Auto-Antibody Production During Experimental Atherosclerosis in ApoE(-/-) Mice

por Hutchinson, Mark A., Park, Han-Sol, Zanotti, Kimberly J., Alvarez-Gonzalez, Juan, Zhang, Jing, Zhang, Li, Telljohann, Richard, Wang, Mingyi, Lakatta, Edward G., Gearhart, Patricia J., Maul, Robert W.
Publicado 2021

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes

por Maul, Robert W., MacCarthy, Thomas, Frank, Ekaterina G., Donigan, Katherine A., McLenigan, Mary P., Yang, William, Saribasak, Huseyin, Huston, Donald E., Lange, Sabine S., Woodgate, Roger, Gearhart, Patricia J.
Publicado 2016

Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

por Lumsden, Joanne M., McCarty, Thomas, Petiniot, Lisa K., Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A., Morse, Herbert C., Gearhart, Patricia J., Wynshaw-Boris, Anthony, Max, Edward E., Hodes, Richard J.
Publicado 2004

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

por Martin, Ophélie A., Thomas, Morgane, Marquet, Marie, Bruzeau, Charlotte, Garot, Armand, Brousse, Mylène, Bender, Sébastien, Carrion, Claire, Choi, Jee Eun, Vuong, Bao Q., Gearhart, Patricia J., Maul, Robert W., Le Noir, Sandrine, Pinaud, Eric
Publicado 2023

Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells

por Ursin, Rebecca L., Dhakal, Santosh, Liu, Hsuan, Jayaraman, Sahana, Park, Han-Sol, Powell, Harrison R., Sherer, Morgan L., Littlefield, Kirsten E., Fink, Ashley L., Ma, Zexu, Mueller, Alice L., Chen, Allison P., Seddu, Kumba, Woldetsadik, Yishak A., Gearhart, Patricia J., Larman, H. Benjamin, Maul, Robert W., Pekosz, Andrew, Klein, Sabra L.
Publicado 2022