Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

por Gao, Rui, Chakraborty, Anirban, Geater, Charlene, Pradhan, Subrata, Gordon, Kara L, Snowden, Jeffrey, Yuan, Subo, Dickey, Audrey S, Choudhary, Sanjeev, Ashizawa, Tetsuo, Ellerby, Lisa M, La Spada, Albert R, Thompson, Leslie M, Hazra, Tapas K, Sarkar, Partha S
Publicado 2019

An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington’s disease models

por Morelli, Kathryn H., Wu, Qian, Gosztyla, Maya L., Liu, Hongshuai, Yao, Minmin, Zhang, Chuangchuang, Chen, Jiaxu, Marina, Ryan J., Lee, Kari, Jones, Krysten L., Huang, Megan Y., Li, Allison, Smith-Geater, Charlene, Thompson, Leslie M., Duan, Wenzhen, Yeo, Gene W.
Publicado 2022

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

por Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest, Thompson, Leslie M.
Publicado 2020

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice

por Olivarria, Gema M., Cheng, Yuting, Furman, Susana, Pachow, Collin, Hohsfield, Lindsay A., Smith-Geater, Charlene, Miramontes, Ricardo, Wu, Jie, Burns, Mara S., Tsourmas, Kate I., Stocksdale, Jennifer, Manlapaz, Cynthia, Yong, William H., Teijaro, John, Edwards, Robert, Green, Kim N., Thompson, Leslie M., Lane, Thomas E.
Publicado 2021

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice

por Olivarria, Gema M., Cheng, Yuting, Furman, Susana, Pachow, Collin, Hohsfield, Lindsay A., Smith-Geater, Charlene, Miramontes, Ricardo, Wu, Jie, Burns, Mara S., Tsourmas, Kate I., Stocksdale, Jennifer, Manlapaz, Cynthia, Yong, William H., Teijaro, John, Edwards, Robert, Green, Kim N., Thompson, Leslie M., Lane, Thomas E.
Publicado 2022

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

por Wu, Gong-Her, Smith-Geater, Charlene, Galaz-Montoya, Jesús G., Gu, Yingli, Gupte, Sanket R., Aviner, Ranen, Mitchell, Patrick G., Hsu, Joy, Miramontes, Ricardo, Wang, Keona Q., Geller, Nicolette R., Hou, Cathy, Danita, Cristina, Joubert, Lydia-Marie, Schmid, Michael F., Yeung, Serena, Frydman, Judith, Mobley, William, Wu, Chengbiao, Thompson, Leslie M., Chiu, Wah
Publicado 2023

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

por Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Publicado 2021