Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

por Wei, Wei, Geer, Mitchell J., Guo, Xinyi, Dolgalev, Igor, Sanjana, Neville E., Neel, Benjamin G.
Publicado 2023

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

por Mazharian, Alexandra, Maître, Blandine, Bornert, Alicia, Hennequin, Desline, Lourenco-Rodrigues, Marc, Geer, Mitchell J., Smith, Christopher W., Heising, Silke, Walter, Michaela, Montel, Florian, Walker, Lucy S. K., de la Salle, Henri, Watson, Steve P., Gachet, Christian, Senis, Yotis A.
Publicado 2022

SHP2 inhibition diminishes KRAS(G12C) cycling and promotes tumor microenvironment remodeling

por Fedele, Carmine, Li, Shuai, Teng, Kai Wen, Foster, Connor J.R., Peng, David, Ran, Hao, Mita, Paolo, Geer, Mitchell J., Hattori, Takamitsu, Koide, Akiko, Wang, Yubao, Tang, Kwan Ho, Leinwand, Joshua, Wang, Wei, Diskin, Brian, Deng, Jiehui, Chen, Ting, Dolgalev, Igor, Ozerdem, Ugur, Miller, George, Koide, Shohei, Wong, Kwok-Kin, Neel, Benjamin G.
Publicado 2020

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

por Nagy, Magdolna, van Geffen, Johanna P., Stegner, David, Adams, David J., Braun, Attila, de Witt, Susanne M., Elvers, Margitta, Geer, Mitchell J., Kuijpers, Marijke J. E., Kunzelmann, Karl, Mori, Jun, Oury, Cécile, Pircher, Joachim, Pleines, Irina, Poole, Alastair W., Senis, Yotis A., Verdoold, Remco, Weber, Christian, Nieswandt, Bernhard, Heemskerk, Johan W. M., Baaten, Constance C. F. M. J.
Publicado 2019

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

por Vögtle, Timo, Sharma, Sumana, Mori, Jun, Nagy, Zoltan, Semeniak, Daniela, Scandola, Cyril, Geer, Mitchell J, Smith, Christopher W, Lane, Jordan, Pollack, Scott, Lassila, Riitta, Jouppila, Annukka, Barr, Alastair J, Ogg, Derek J, Howard, Tina D, McMiken, Helen J, Warwicker, Juli, Geh, Catherine, Rowlinson, Rachel, Abbott, W Mark, Eckly, Anita, Schulze, Harald, Wright, Gavin J, Mazharian, Alexandra, Fütterer, Klaus, Rajesh, Sundaresan, Douglas, Michael R, Senis, Yotis A
Publicado 2019