A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

por Tanton, Helen, Sewastianik, Tomasz, Seo, Hyuk-Soo, Remillard, David, Pierre, Roodolph St., Bala, Pratyusha, Aitymbayev, Daulet, Dennis, Peter, Adler, Keith, Geffken, Ezekiel, Yeoh, Zoe, Vangos, Nicholas, Garbicz, Filip, Scott, David, Sethi, Nilay, Bradner, James, Dhe-Paganon, Sirano, Carrasco, Ruben D.
Publicado 2022

Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival

por Fukuda, Yusuke, Pazyra-Murphy, Maria F., Silagi, Elizabeth S., Tasdemir-Yilmaz, Ozge E., Li, Yihang, Rose, Lillian, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Seo, Hyuk-Soo, Adelmant, Guillaume, Bird, Gregory H., Walensky, Loren D., Marto, Jarrod A., Dhe-Paganon, Sirano, Segal, Rosalind A.
Publicado 2020

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

por Fan, Mengyang, Lu, Wenchao, Che, Jianwei, Kwiatkowski, Nicholas P, Gao, Yang, Seo, Hyuk-Soo, Ficarro, Scott B, Gokhale, Prafulla C, Liu, Yao, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Kuljanin, Miljan, Ji, Wenzhi, Jiang, Jie, He, Zhixiang, Tse, Jason, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Mancias, Joseph D, Marto, Jarrod A, Dhe-Paganon, Sirano, Zhang, Tinghu, Gray, Nathanael S
Publicado 2022

Identification of a potent and selective covalent Pin1 inhibitor

por Pinch, Benika J., Doctor, Zainab M., Nabet, Behnam, Browne, Christopher M., Seo, Hyuk-Soo, Mohardt, Mikaela L., Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D., Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Tan, Li, Ficarro, Scott B., London, Nir, Marto, Jarrod A., Buratowski, Stephen, Dhe-Paganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S.
Publicado 2020