Immune Therapeutic Strategies in Chronic Hepatitis B Virus Infection: Virus or Inflammation Control?

por Bertoletti, Antonio, Gehring, Adam J.
Publicado 2013

HBV-Specific Adaptive Immunity

por Bertoletti, Antonio, Tan, Anthony T., Gehring, Adam J.
Publicado 2009

RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies

por Wooddell, Christine I., Gehring, Adam J., Yuen, Man-Fung, Given, Bruce D.
Publicado 2021

HepG2-NTCP Subclones Exhibiting High Susceptibility to Hepatitis B Virus Infection

por Zahoor, Muhammad Atif, Kuipery, Adrian, Mosa, Alexander I., Gehring, Adam J., Feld, Jordan J.
Publicado 2022

Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections

por Banu, Nasirah, Chia, Adeline, Ho, Zi Zong, Garcia, Alfonso Tan, Paravasivam, Komathi, Grotenbreg, Gijsbert M., Bertoletti, Antonio, Gehring, Adam J.
Publicado 2014

Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients

por Chua, Conan G., Mehrotra, Aman, Mazzulli, Tony, Wong, David K., Feld, Jordan J., Janssen, Harry L. A., Gehring, Adam J.
Publicado 2020

Functional Exhaustion of HBV-Specific CD8 T Cells Impedes PD-L1 Blockade Efficacy in Chronic HBV Infection

por Ferrando-Martinez, Sara, Snell Bennett, Angie, Lino, Elisabete, Gehring, Adam J., Feld, Jordan, Janssen, Harry L. A., Robbins, Scott H.
Publicado 2021

Trained immunity in newborn infants of HBV-infected mothers

por Hong, Michelle, Sandalova, Elena, Low, Diana, Gehring, Adam J., Fieni, Stefania, Amadei, Barbara, Urbani, Simonetta, Chong, Yap-Seng, Guccione, Ernesto, Bertoletti, Antonio
Publicado 2015

Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus

por Mosa, Alexander I., Campo, David S., Khudyakov, Yury, AbouHaidar, Mounir G., Gehring, Adam J., Zahoor, Atif, Ball, Jonathan K., Urbanowicz, Richard A., Feld, Jordan J.
Publicado 2023

Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

por Santer, Deanna M., Li, Daniel, Ghosheh, Yanal, Zahoor, Muhammad Atif, Prajapati, Dhanvi, Hansen, Bettina E., Tyrrell, D. Lorne J., Feld, Jordan J., Gehring, Adam J.
Publicado 2022

Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

por Low, Jianrong L., Naidoo, Anneta, Yeo, Gladys, Gehring, Adam J., Ho, Zi Zong, Yau, Yin Hoe, Shochat, Susana G., Kranz, David M., Bertoletti, Antonio, Grotenbreg, Gijsbert M.
Publicado 2012

Licensing Virus-Specific T Cells to Secrete the Neutrophil Attracting Chemokine CXCL-8 during Hepatitis B Virus Infection

por Gehring, Adam J., Koh, Sarene, Chia, Adeline, Paramasivam, Komathi, Chew, Valerie Suk Peng, Ho, Zi Zong, Lee, Kang Hoe, Maini, Mala K., Madhavan, Krishnakumar, Lim, Seng Gee, Bertoletti, Antonio
Publicado 2011

The Human Male Liver Is Predisposed to Inflammation Via Enhanced Myeloid Responses to Inflammatory Triggers

por Kuipery, Adrian, Mahamed, Deeqa, Nkongolo, Shirin, D’Angelo, June Ann, Johnson Valiente, Alexandra, Mehrotra, Aman, Chapman, William C., Horton, Peter, McGilvray, Ian, Janssen, Harry L. A., Gehring, Adam J.
Publicado 2022

Efficacy of antiviral therapy and host–virus interactions visualised using serial liver sampling with fine-needle aspirates

por Kim, Samuel C., Wallin, Jeffrey J., Ghosheh, Yanal, Zahoor, Muhammad Atif, Sanchez Vasquez, Juan Diego, Nkongolo, Shirin, Fung, Scott, Mendez, Patricia, Feld, Jordan J., Janssen, Harry L.A., Gehring, Adam J.
Publicado 2023

A Practical Approach to Immunotherapy of Hepatocellular Carcinoma Using T Cells Redirected Against Hepatitis B Virus

por Koh, Sarene, Shimasaki, Noriko, Suwanarusk, Rossarin, Ho, Zi Zong, Chia, Adeline, Banu, Nasirah, Wu Howland, Shanshan, Ong, Alice Soh Meoy, Gehring, Adam J, Stauss, Hans, Renia, Laurent, Sällberg, Matti, Campana, Dario, Bertoletti, Antonio
Publicado 2013

Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8(+) T cells

por Nkongolo, Shirin, Mahamed, Deeqa, Kuipery, Adrian, Sanchez Vasquez, Juan D., Kim, Samuel C., Mehrotra, Aman, Patel, Anjali, Hu, Christine, McGilvray, Ian, Feld, Jordan J., Fung, Scott, Chen, Diana, Wallin, Jeffrey J., Gaggar, Anuj, Janssen, Harry L.A., Gehring, Adam J.
Publicado 2023

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

por Jo, Juandy, Tan, Anthony T., Ussher, James E., Sandalova, Elena, Tang, Xin-Zi, Tan-Garcia, Alfonso, To, Natalie, Hong, Michelle, Chia, Adeline, Gill, Upkar S., Kennedy, Patrick T., Tan, Kai Chah, Lee, Kang Hoe, De Libero, Gennaro, Gehring, Adam J., Willberg, Christian B., Klenerman, Paul, Bertoletti, Antonio
Publicado 2014

Conditional ligands for Asian HLA variants facilitate the definition of CD8(+) T‐cell responses in acute and chronic viral diseases

por Chang, Cynthia X. L., Tan, Anthony T., Or, Ming Yan, Toh, Kai Yee, Lim, Pei Yiing, Chia, Adeline S. E., Froesig, Thomas M., Nadua, Karen D., Oh, Hsueh‐Ling J., Leong, Hoe Nam, Hadrup, Sine R., Gehring, Adam J., Tan, Yee‐Joo, Bertoletti, Antonio, Grotenbreg, Gijsbert M.
Publicado 2013

A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance

por King, Thomas H., Kemmler, Charles B., Guo, Zhimin, Mann, Derrick, Lu, Yingnian, Coeshott, Claire, Gehring, Adam J., Bertoletti, Antonio, Ho, Zi Z., Delaney, William, Gaggar, Anuj, Subramanian, G. Mani, McHutchison, John G., Shrivastava, Shikha, Lee, Yu-Jin L., Kottilil, Shyamasundaran, Bellgrau, Donald, Rodell, Timothy, Apelian, David
Publicado 2014

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

por Feld, Jordan J, Kandel, Christopher, Biondi, Mia J, Kozak, Robert A, Zahoor, Muhammad Atif, Lemieux, Camille, Borgia, Sergio M, Boggild, Andrea K, Powis, Jeff, McCready, Janine, Tan, Darrell H S, Chan, Tiffany, Coburn, Bryan, Kumar, Deepali, Humar, Atul, Chan, Adrienne, O'Neil, Braden, Noureldin, Seham, Booth, Joshua, Hong, Rachel, Smookler, David, Aleyadeh, Wesam, Patel, Anjali, Barber, Bethany, Casey, Julia, Hiebert, Ryan, Mistry, Henna, Choong, Ingrid, Hislop, Colin, Santer, Deanna M, Lorne Tyrrell, D, Glenn, Jeffrey S, Gehring, Adam J, Janssen, Harry L A, Hansen, Bettina E
Publicado 2021