Circadian clocks: from stem cells to tissue homeostasis and regeneration

por Dierickx, Pieterjan, Van Laake, Linda W, Geijsen, Niels
Publicado 2017

Extending the CRISPR toolbox for C. elegans: Cpf1 as an alternative gene editing system for AT-rich sequences

por Ebbing, Annabel, Shang, Peng, Geijsen, Niels, Korswagen, Hendrik
Publicado 2017

Ligation-assisted homologous recombination enables precise genome editing by deploying both MMEJ and HDR

por Zhao, Zhihan, Shang, Peng, Sage, Fanny, Geijsen, Niels
Publicado 2022

Cloning-free CRISPR

por Arbab, Mandana, Srinivasan, Sharanya, Hashimoto, Tatsunori, Geijsen, Niels, Sherwood, Richard I.
Publicado 2015

Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression

por Lin, Lin, Holmes, Benjamin, Shen, Max W., Kammeron, Darnell, Geijsen, Niels, Gifford, David K., Sherwood, Richard I.
Publicado 2020

Knock-Out Serum Replacement and Melatonin Effects on Germ Cell Differentiation in Murine Testicular Explant Cultures

por Reda, Ahmed, Albalushi, Halima, Montalvo, Sheyla Cisneros, Nurmio, Mirja, Sahin, Zeliha, Hou, Mi, Geijsen, Niels, Toppari, Jorma, Söder, Olle, Stukenborg, Jan-Bernd
Publicado 2017

Circadian networks in human embryonic stem cell‐derived cardiomyocytes

por Dierickx, Pieterjan, Vermunt, Marit W, Muraro, Mauro J, Creyghton, Menno P, Doevendans, Pieter A, van Oudenaarden, Alexander, Geijsen, Niels, Van Laake, Linda W
Publicado 2017

Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers

por Chen, Chen, Pla‐Palacín, Iris, Baptista, Pedro M., Shang, Peng, Oosterhoff, Loes A., van Wolferen, Monique E., Penning, Louis C., Geijsen, Niels, Spee, Bart
Publicado 2018

Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen

por Ashoti, Ator, Limone, Francesco, van Kranenburg, Melissa, Alemany, Anna, Baak, Mirna, Vivié, Judith, Piccioni, Frederica, Dijkers, Pascale F., Creyghton, Menno, Eggan, Kevin, Geijsen, Niels
Publicado 2022

An ES-Like Pluripotent State in FGF-Dependent Murine iPS cells

por Di Stefano, Bruno, Buecker, Christa, Ungaro, Federica, Prigione, Alessandro, Chen, Hsu-Hsin, Welling, Maaike, Eijpe, Maureen, Mostoslavsky, Gustavo, Tesar, Paul, Adjaye, James, Geijsen, Niels, Broccoli, Vania
Publicado 2010

Cell Lineage Specific Distribution of H3K27 Trimethylation Accumulation in an In Vitro Model for Human Implantation

por Teklenburg, Gijs, Weimar, Charlotte H. E., Fauser, Bart C. J. M., Macklon, Nick, Geijsen, Niels, Heijnen, Cobi J., Chuva de Sousa Lopes, Susana M., Kuijk, Ewart W.
Publicado 2012

Modulating CRISPR-Cas Genome Editing Using Guide-Complementary DNA Oligonucleotides

por Swartjes, Thomas, Shang, Peng, van den Berg, Dennis T.M., Künne, Tim, Geijsen, Niels, Brouns, Stan J.J., van der Oost, John, Staals, Raymond H.J., Notebaart, Richard A.
Publicado 2022

Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

por Castelijns, Bas, Baak, Mirna L., Timpanaro, Ilia S., Wiggers, Caroline R. M., Vermunt, Marit W., Shang, Peng, Kondova, Ivanela, Geeven, Geert, Bianchi, Valerio, de Laat, Wouter, Geijsen, Niels, Creyghton, Menno P.
Publicado 2020

High level of polarized engraftment of porcine intrahepatic cholangiocyte organoids in decellularized liver scaffolds

por Krüger, Melanie, Samsom, Roos‐Anne, Oosterhoff, Loes A., van Wolferen, Monique E., Kooistra, Hans S., Geijsen, Niels, Penning, Louis C., Kock, Linda M., Sainz‐Arnal, Pilar, Baptista, Pedro M., Spee, Bart
Publicado 2022

Normothermic Ex Vivo Liver Platform Using Porcine Slaughterhouse Livers for Disease Modeling

por Krüger, Melanie, Ruppelt, Alicia, Kappler, Benjamin, Van Soest, Elke, Samsom, Roos Anne, Grinwis, Guy C. M., Geijsen, Niels, Helms, J. Bernd, Stijnen, Marco, Kock, Linda M., Rasponi, Marco, Kooistra, Hans S., Spee, Bart
Publicado 2022

DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells

por Chen, Hsu-Hsin, Welling, Maaike, Bloch, Donald B., Muñoz, Javier, Mientjes, Edwin, Chen, Xinjie, Tramp, Cody, Wu, Jie, Yabuuchi, Akiko, Chou, Yu-Fen, Buecker, Christa, Krainer, Adrian, Willemsen, Rob, Heck, Albert J., Geijsen, Niels
Publicado 2014

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation

por de Esch, Celine E.F., Ghazvini, Mehrnaz, Loos, Friedemann, Schelling-Kazaryan, Nune, Widagdo, W., Munshi, Shashini T., van der Wal, Erik, Douben, Hannie, Gunhanlar, Nilhan, Kushner, Steven A., Pijnappel, W.W.M. Pim, de Vrij, Femke M.S., Geijsen, Niels, Gribnau, Joost, Willemsen, Rob
Publicado 2014

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

por Nantasanti, Sathidpak, Spee, Bart, Kruitwagen, Hedwig S., Chen, Chen, Geijsen, Niels, Oosterhoff, Loes A., van Wolferen, Monique E., Pelaez, Nicolas, Fieten, Hille, Wubbolts, Richard W., Grinwis, Guy C., Chan, Jefferson, Huch, Meritxell, Vries, Robert R.G., Clevers, Hans, de Bruin, Alain, Rothuizen, Jan, Penning, Louis C., Schotanus, Baukje A.
Publicado 2015

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

por Kruitwagen, Hedwig S., Oosterhoff, Loes A., Vernooij, Ingrid G.W.H., Schrall, Ingrid M., van Wolferen, Monique E., Bannink, Farah, Roesch, Camille, van Uden, Lisa, Molenaar, Martijn R., Helms, J. Bernd, Grinwis, Guy C.M., Verstegen, Monique M.A., van der Laan, Luc J.W., Huch, Meritxell, Geijsen, Niels, Vries, Robert G., Clevers, Hans, Rothuizen, Jan, Schotanus, Baukje A., Penning, Louis C., Spee, Bart
Publicado 2017

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

por Kruitwagen, Hedwig S., Oosterhoff, Loes A., van Wolferen, Monique E., Chen, Chen, Nantasanti Assawarachan, Sathidpak, Schneeberger, Kerstin, Kummeling, Anne, van Straten, Giora, Akkerdaas, Ies C., Vinke, Christel R., van Steenbeek, Frank G., van Bruggen, Leonie W.L., Wolfswinkel, Jeannette, Grinwis, Guy C.M., Fuchs, Sabine A., Gehart, Helmuth, Geijsen, Niels, Vries, Robert G., Clevers, Hans, Rothuizen, Jan, Schotanus, Baukje A., Penning, Louis C., Spee, Bart
Publicado 2020