Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons

por Genc, Baris, Gozutok, Oge, Ozdinler, P. Hande
Publicado 2019

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord

por Genc, Baris, Gozutok, Oge, Kocak, Nuran, Ozdinler, P. Hande
Publicado 2020

A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance

por Genç, Barış, Özdinler, P. Hande, Mendoza, April E, Erzurumlu, Reha S
Publicado 2004

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

por Jara, Javier H., Genç, Barış, Klessner, Jodi L., Özdinler, P. Hande
Publicado 2014

NU-9 improves health of hSOD1(G93A) mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone

por Genç, Barış, Gautam, Mukesh, Helmold, Benjamin R., Koçak, Nuran, Günay, Aksu, Goshu, Gashaw M., Silverman, Richard B., Hande Ozdinler, P.
Publicado 2022

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

por Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Publicado 2022

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

por Jara, Javier H., Genç, Barış, Cox, Gregory A., Bohn, Martha C., Roos, Raymond P., Macklis, Jeffrey D., Ulupınar, Emel, Özdinler, P. Hande
Publicado 2015

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

por Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Publicado 2021

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line

por Genç, Barış, Lagrimas, Amiko Krisa Bunag, Kuru, Pınar, Hess, Robert, Tu, Michael William, Menichella, Daniela Maria, Miller, Richard J., Paller, Amy S., Özdinler, P. Hande
Publicado 2015

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

por Genç, Barış, Jara, Javier H., Lagrimas, Amiko K. B., Pytel, Peter, Roos, Raymond P., Mesulam, M. Marsel, Geula, Changiz, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2017

Evidence for an early innate immune response in the motor cortex of ALS

por Jara, Javier H., Genç, Barış, Stanford, Macdonell J., Pytel, Peter, Roos, Raymond P., Weintraub, Sandra, Mesulam, M. Marsel, Bigio, Eileen H., Miller, Richard J., Özdinler, P. Hande
Publicado 2017

Complementary feature selection from alternative splicing events and gene expression for phenotype prediction

por Labuzzetta, Charles J, Antonio, Margaret L, Watson, Patricia M, Wilson, Robert C, Laboissonniere, Lauren A, Trimarchi, Jeffrey M, Genc, Baris, Ozdinler, P Hande, Watson, Dennis K, Anderson, Paul E
Publicado 2016

Absence of UCHL 1 function leads to selective motor neuropathy

por Genç, Barış, Jara, Javier H., Schultz, Megan C., Manuel, Marin, Stanford, Macdonell J., Gautam, Mukesh, Klessner, Jodi L., Sekerkova, Gabriella, Heller, Daniel B., Cox, Gregory A., Heckman, Charles J., DiDonato, Christine J., Özdinler, P. Hande
Publicado 2016