The role of tau in neurodegeneration

por Gendron, Tania F, Petrucelli, Leonard
Publicado 2009

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration

por Gendron, Tania F., Petrucelli, Leonard
Publicado 2011

Biomarkers for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Associated With Hexanucleotide Expansion Mutations in C9orf72

por Floeter, Mary Kay, Gendron, Tania F.
Publicado 2018

Does Obesity-Induced τ Phosphorylation Tip the Scale Toward Dementia?

por Gendron, Tania F., Zhang, Yong-Jie, Petrucelli, Leonard
Publicado 2013

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

por Yuva-Aydemir, Yeliz, Almeida, Sandra, Krishnan, Gopinath, Gendron, Tania F., Gao, Fen-Biao
Publicado 2019

ARHGEF28 p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion

por Farhan, Sali M.K., Gendron, Tania F., Petrucelli, Leonard, Hegele, Robert A., Strong, Michael J.
Publicado 2017

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

por Cook, Casey, Gendron, Tania F., Scheffel, Kristyn, Carlomagno, Yari, Dunmore, Judy, DeTure, Michael, Petrucelli, Leonard
Publicado 2012

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

por Zhang, Yong-Jie, Gendron, Tania F, Xu, Ya-Fei, Ko, Li-Wen, Yen, Shu-Hui, Petrucelli, Leonard
Publicado 2010

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

por Esanov, Rustam, Cabrera, Gabriela Toro, Andrade, Nadja S., Gendron, Tania F., Brown, Robert H., Benatar, Michael, Wahlestedt, Claes, Mueller, Christian, Zeier, Zane
Publicado 2017

Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

por Sakae, Nobutaka, Bieniek, Kevin F., Zhang, Yong-Jie, Ross, Kelly, Gendron, Tania F., Murray, Melissa E., Rademakers, Rosa, Petrucelli, Leonard, Dickson, Dennis W.
Publicado 2018

Single nucleus multiome analysis of the prefrontal cortex from C9orf72 ALS/FTD patients illuminates pathways affected during disease progression

por Wang, Hsiao-Lin V., Veire, Austin M., Gendron, Tania F., Gearing, Marla, Glass, Jonathan D., Jin, Peng, Corces, Victor G., McEachin, Zachary T.
Publicado 2023

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

por Cook, Casey, Carlomagno, Yari, Gendron, Tania F., Dunmore, Judy, Scheffel, Kristyn, Stetler, Caroline, Davis, Mary, Dickson, Dennis, Jarpe, Matthew, DeTure, Michael, Petrucelli, Leonard
Publicado 2014

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

por Zhang, Yong-Jie, Caulfield, Thomas, Xu, Ya-Fei, Gendron, Tania F., Hubbard, Jaime, Stetler, Caroline, Sasaguri, Hiroki, Whitelaw, Ena C., Cai, Shuyi, Lee, Wing Cheung, Petrucelli, Leonard
Publicado 2013

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA

por Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido-Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D
Publicado 2014

Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

por Belzil, Veronique V., Bauer, Peter O., Prudencio, Mercedes, Gendron, Tania F., Stetler, Caroline T., Yan, Irene K., Pregent, Luc, Daughrity, Lillian, Baker, Matthew C., Rademakers, Rosa, Boylan, Kevin, Patel, Tushar C., Dickson, Dennis W., Petrucelli, Leonard
Publicado 2013

Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial

por Krull, Ashley A., Setter, Deborah O., Gendron, Tania F., Hrstka, Sybil C. L., Polzin, Michael J., Hart, Joseph, Dudakovic, Amel, Madigan, Nicolas N., Dietz, Allan B., Windebank, Anthony J., van Wijnen, Andre J., Staff, Nathan P.
Publicado 2021

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

por Andrade, Nadja S., Ramic, Melina, Esanov, Rustam, Liu, Wenjun, Rybin, Mathew J., Gaidosh, Gabriel, Abdallah, Abbas, Del’Olio, Samuel, Huff, Tyler C., Chee, Nancy T., Anatha, Sadhana, Gendron, Tania F., Wahlestedt, Claes, Zhang, Yanbin, Benatar, Michael, Mueller, Christian, Zeier, Zane
Publicado 2020

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

por Sonobe, Yoshifumi, Aburas, Jihad, Krishnan, Gopinath, Fleming, Andrew C., Ghadge, Ghanashyam, Islam, Priota, Warren, Eleanor C., Gu, Yuanzheng, Kankel, Mark W., Brown, André E. X., Kiskinis, Evangelos, Gendron, Tania F., Gao, Fen-Biao, Roos, Raymond P., Kratsios, Paschalis
Publicado 2021

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

por Almeida, Sandra, Gascon, Eduardo, Tran, Hélène, Chou, Hsin Jung, Gendron, Tania F., DeGroot, Steven, Tapper, Andrew R., Sellier, Chantal, Charlet-Berguerand, Nicolas, Karydas, Anna, Seeley, William W., Boxer, Adam L., Petrucelli, Leonard, Miller, Bruce L., Gao, Fen-Biao
Publicado 2013

Erratum to: Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

por Almeida, Sandra, Gascon, Eduardo, Tran, Hélène, Chou, Hsin Jung, Gendron, Tania F., DeGroot, Steven, Tapper, Andrew R., Sellier, Chantal, Charlet-Berguerand, Nicolas, Karydas, Anna, Seeley, William W., Boxer, Adam L., Petrucelli, Leonard, Miller, Bruce L., Gao, Fen-Biao
Publicado 2014