Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

por Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Publicado 2017

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

por Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Publicado 2018

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

por Zuhl, Andrea M., Nolan, Charles E., Brodney, Michael A., Niessen, Sherry, Atchison, Kevin, Houle, Christopher, Karanian, David A., Ambroise, Claude, Brulet, Jeffrey W., Beck, Elizabeth M., Doran, Shawn D., O'Neill, Brian T., am Ende, Christopher W., Chang, Cheng, Geoghegan, Kieran F., West, Graham M., Judkins, Joshua C., Hou, Xinjun, Riddell, David R., Johnson, Douglas S.
Publicado 2016

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

por Esquejo, Ryan M., Salatto, Christopher T., Delmore, Jake, Albuquerque, Bina, Reyes, Allan, Shi, Yuji, Moccia, Rob, Cokorinos, Emily, Peloquin, Matthew, Monetti, Mara, Barricklow, Jason, Bollinger, Eliza, Smith, Brennan K., Day, Emily A., Nguyen, Chuong, Geoghegan, Kieran F., Kreeger, John M., Opsahl, Alan, Ward, Jessica, Kalgutkar, Amit S., Tess, David, Butler, Lynne, Shirai, Norimitsu, Osborne, Timothy F., Steinberg, Gregory R., Birnbaum, Morris J., Cameron, Kimberly O., Miller, Russell A.
Publicado 2018

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

por Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli
Publicado 2016