Regulation of CAR and PXR Expression in Health and Disease

por Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine
Publicado 2020

Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

por Gerbal-Chaloin, Sabine, Briolotti, Philippe, Daujat-Chavanieu, Martine, Rasmussen, Martin Krøyer
Publicado 2021

p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor

por Testoni, B, Schinzari, V, Guerrieri, F, Gerbal-Chaloin, S, Blandino, G, Levrero, M
Publicado 2011

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

por Rasmussen, Martin Krøyer, Balaguer, Patrick, Ekstrand, Bo, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine
Publicado 2016

Comparison of Hepatic-like Cell Production from Human Embryonic Stem Cells and Adult Liver Progenitor Cells: CAR Transduction Activates a Battery of Detoxification Genes

por Funakoshi, Natalie, Duret, Cédric, Pascussi, Jean-Marc, Blanc, Pierre, Maurel, Patrick, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine
Publicado 2011

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

por Smutny, Tomas, Dusek, Jan, Hyrsova, Lucie, Nekvindova, Jana, Horvatova, Alzbeta, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Publicado 2020

Dissecting the First Transcriptional Divergence During Human Embryonic Development

por Bai, Qiang, Assou, Said, Haouzi, Delphine, Ramirez, Jean-Marie, Monzo, Cécile, Becker, Fabienne, Gerbal-Chaloin, Sabine, Hamamah, Samir, De Vos, John
Publicado 2011

The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells

por Guerrieri, F, Piconese, S, Lacoste, C, Schinzari, V, Testoni, B, Valogne, Y, Gerbal-Chaloin, S, Samuel, D, Bréchot, C, Faivre, J, Levrero, M
Publicado 2013

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

por Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Publicado 2020

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

por Vinci, Bruna, Duret, Cédric, Klieber, Sylvie, Gerbal-Chaloin, Sabine, Sa-Cunha, Antonio, Laporte, Sylvain, Suc, Bertrand, Maurel, Patrick, Ahluwalia, Arti, Daujat-Chavanieu, Martine
Publicado 2011

Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation

por Khan, Abrar Ul Haq, Salehi, Hamideh, Alexia, Catherine, Valdivielso, Jose M., Bozic, Milica, Lopez-Mejia, Isabel C., Fajas, Lluis, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Gitenay, Delphine, Villalba, Martin
Publicado 2022

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

por Riou, Rozenn, Ladli, Meriem, Gerbal-Chaloin, Sabine, Bossard, Pascale, Gougelet, Angélique, Godard, Cécile, Loesch, Robin, Lagoutte, Isabelle, Lager, Franck, Calderaro, Julien, Dos Santos, Alexandre, Wang, Zhong, Verdier, Frédérique, Colnot, Sabine
Publicado 2020

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

por Creusot, Nicolas, Gassiot, Matthieu, Alaterre, Elina, Chiavarina, Barbara, Grimaldi, Marina, Boulahtouf, Abdelhay, Toporova, Lucia, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Matheux, Alice, Rahmani, Roger, Gongora, Céline, Evrard, Alexandre, Pourquier, Philippe, Balaguer, Patrick
Publicado 2020

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

por Delfosse, Vanessa, Dendele, Béatrice, Huet, Tiphaine, Grimaldi, Marina, Boulahtouf, Abdelhay, Gerbal-Chaloin, Sabine, Beucher, Bertrand, Roecklin, Dominique, Muller, Christina, Rahmani, Roger, Cavaillès, Vincent, Daujat-Chavanieu, Martine, Vivat, Valérie, Pascussi, Jean-Marc, Balaguer, Patrick, Bourguet, William
Publicado 2015

Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

por Nakhle, Jean, Khattar, Khattar, Özkan, Tülin, Boughlita, Adel, Abba Moussa, Daouda, Darlix, Amélie, Lorcy, Frédérique, Rigau, Valérie, Bauchet, Luc, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Bellvert, Floriant, Turchi, Laurent, Virolle, Thierry, Hugnot, Jean-Philippe, Buisine, Nicolas, Galloni, Mireille, Dardalhon, Valérie, Rodriguez, Anne-Marie, Vignais, Marie-Luce
Publicado 2023

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

por Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Gerbal-Chaloin, Sabine, Gondeau, Claire, Vo, Dang-Nghiem, Belkahla, Sana, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Bozic, Milica, Valdivielso, Jose M., Bejjani, Fabienne, Jariel, Isabelle, Lopez-Mejia, Isabel C., Fajas, Lluis, Lecellier, Charles-Henri, Hernandez, Javier, Daujat, Martine, Villalba, Martin
Publicado 2017

Mitochondrial Complex I activity signals antioxidant response through ERK5

por Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Garaude, Johan, Vo, Dang-Nghiem, Belkhala, Sana, Gerbal-Chaloin, Sabine, Gondeau, Claire, Daujat-Chavanieu, Martine, Delettre, Cécile, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Anel, Alberto, Cuezva, José M., Enriquez, Jose A., Cartron, Guillaume, Lecellier, Charles-Henri, Hernandez, Javier, Villalba, Martin
Publicado 2018