Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence–Function Space and Genome Context to Discover Novel Functions

por Gerlt, John A.
Publicado 2017

Can sequence determine function?

por Gerlt, John A, Babbitt, Patricia C
Publicado 2000

RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry

por Oberg, Nils, Precord, Timothy W., Mitchell, Douglas A., Gerlt, John A.
Publicado 2021

Pyridoxal 5’-phosphate synthesis and salvage in Bacteria and Archaea: predicting pathway variant distributions and holes

por Denise, Rémi, Babor, Jill, Gerlt, John A., de Crécy-Lagard, Valérie
Publicado 2023

A gold standard set of mechanistically diverse enzyme superfamilies

por Brown, Shoshana D, Gerlt, John A, Seffernick, Jennifer L, Babbitt, Patricia C
Publicado 2006

Galactaro δ-Lactone Isomerase: Lactone Isomerization by a Member of the Amidohydrolase Superfamily

por Bouvier, Jason T., Groninger-Poe, Fiona P., Vetting, Matthew, Almo, Steven C., Gerlt, John A.
Publicado 2014

Enzyme Architecture: Deconstruction of the Enzyme-Activating Phosphodianion Interactions of Orotidine 5′-Monophosphate Decarboxylase

por Goldman, Lawrence M., Amyes, Tina L., Goryanova, Bogdana, Gerlt, John A., Richard, John P.
Publicado 2014

Identification of the in Vivo Function of the High-Efficiency d-Mannonate Dehydratase in Caulobacter crescentus NA1000 from the Enolase Superfamily

por Wichelecki, Daniel J., Graff, Dylan C., Al-Obaidi, Nawar, Almo, Steven C., Gerlt, John A.
Publicado 2014

Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5′-Monophosphate Decarboxylase

por Goryanova, Bogdana, Goldman, Lawrence M., Ming, Shonoi, Amyes, Tina L., Gerlt, John A., Richard, John P.
Publicado 2015

Discovery of a Novel l-Lyxonate Degradation Pathway in Pseudomonas aeruginosa PAO1

por Ghasempur, Salehe, Eswaramoorthy, Subramaniam, Hillerich, Brandan S., Seidel, Ronald D., Swaminathan, Subramanyam, Almo, Steven C., Gerlt, John A.
Publicado 2014

Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ

por Wichelecki, Daniel J., Froese, D. Sean, Kopec, Jolanta, Muniz, Joao R.C., Yue, Wyatt W., Gerlt, John A.
Publicado 2014

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis

por Reyes, Archie C., Plache, David C., Koudelka, Astrid P., Amyes, Tina L., Gerlt, John A., Richard, John P.
Publicado 2018

Investigating the Physiological Roles of Low-Efficiency d-Mannonate and d-Gluconate Dehydratases in the Enolase Superfamily: Pathways for the Catabolism of l-Gulonate and l-Idonate

por Wichelecki, Daniel J., Vendiola, Jean Alyxa Ferolin, Jones, Amy M., Al-Obaidi, Nawar, Almo, Steven C., Gerlt, John A.
Publicado 2014

Evolution of Enzymatic Activities in the Enolase Superfamily: Galactarate Dehydratase III from Agrobacterium tumefaciens C58

por Groninger-Poe, Fiona P., Bouvier, Jason T., Vetting, Matthew W., Kalyanaraman, Chakrapani, Kumar, Ritesh, Almo, Steven C., Jacobson, Matthew P., Gerlt, John A.
Publicado 2014

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways

por Cho, Kyuil, Evans, Bradley S., Wood, B. McKay, Kumar, Ritesh, Erb, Tobias J., Warlick, Benjamin P., Gerlt, John A., Sweedler, Jonathan V.
Publicado 2014

A RubisCO like protein links SAM metabolism with isoprenoid biosynthesis

por Erb, Tobias J., Evans, Bradley S., Cho, Kyuil, Warlick, Benjamin P., Sriram, Jaya, Wood, B. McKay, Imker, Heidi J., Sweedler, Jonathan V., Tabita, F. Robert, Gerlt, John A.
Publicado 2012

Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine

por Kumar, Ritesh, Zhao, Suwen, Vetting, Matthew W., Wood, B. McKay, Sakai, Ayano, Cho, Kyuil, Solbiati, José, Almo, Steven C., Sweedler, Jonathan V., Jacobson, Matthew P., Gerlt, John A., Cronan, John E.
Publicado 2014

The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus

por Garber, Jolene M., Nothaft, Harald, Pluvinage, Ben, Stahl, Martin, Bian, Xiaoming, Porfirio, Sara, Enriquez, Amber, Butcher, James, Huang, Hua, Glushka, John, Line, Eric, Gerlt, John A., Azadi, Parastoo, Stintzi, Alain, Boraston, Alisdair B., Szymanski, Christine M.
Publicado 2020

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup

por Wichelecki, Daniel J., Balthazor, Bryan M., Chau, Anthony C., Vetting, Matthew W., Fedorov, Alexander A., Fedorov, Elena V., Lukk, Tiit, Patskovsky, Yury V., Stead, Mark B., Hillerich, Brandan S., Seidel, Ronald D., Almo, Steven C., Gerlt, John A.
Publicado 2014

Discovery of new enzymes and metabolic pathways using structure and genome context

por Zhao, Suwen, Kumar, Ritesh, Sakai, Ayano, Vetting, Matthew W., Wood, B. McKay, Brown, Shoshana, Bonanno, Jeffery B., Hillerich, Brandan S., Seidel, Ronald D., Babbitt, Patricia C., Almo, Steven C., Sweedler, Jonathan V., Gerlt, John A., Cronan, John E., Jacobson, Matthew P.
Publicado 2013