Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2

por Mélin, Léa, Gesner, Emily, Attwell, Sarah, Kharenko, Olesya A., van der Horst, Edward H., Hansen, Henrik C., Gagnon, Alexandre
Publicado 2021

RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

por McLure, Kevin G., Gesner, Emily M., Tsujikawa, Laura, Kharenko, Olesya A., Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K., Wong, Norman C. W., Wagner, Gregory S., Hansen, Henrik C., Young, Peter R.
Publicado 2013

BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

por Kim, Dae-Hwan, Sun, Duanchen, Storck, William K., Welker Leng, Katherine, Jenkins, Chelsea, Coleman, Daniel J., Sampson, David, Guan, Xiangnan, Kumaraswamy, Anbarasu, Rodansky, Eva S., Urrutia, Joshua A., Schwartzman, Jacob A., Zhang, Chao, Beltran, Himisha, Labrecque, Mark P., Morrissey, Colm, Lucas, Jared M., Coleman, Ilsa M., Nelson, Peter S., Corey, Eva, Handelman, Samuel K., Sexton, Jonathan Z., Aggarwal, Rahul, Abida, Wassim, Feng, Felix Y., Small, Eric J., Spratt, Daniel E., Bankhead, Armand, Rao, Arvind, Gesner, Emily M., Attwell, Sarah, Lakhotia, Sanjay, Campeau, Eric, Yates, Joel A., Xia, Zheng, Alumkal, Joshi J.
Publicado 2021