Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes

por Johnson, Oleta T., Gestwicki, Jason E.
Publicado 2022

Direct and Propagated Effects of Small Molecules on Protein–Protein Interaction Networks

por Cesa, Laura C., Mapp, Anna K., Gestwicki, Jason E.
Publicado 2015

The interactions of molecular chaperones with client proteins: why are they so weak?

por Arhar, Taylor, Shkedi, Arielle, Nadel, Cory M., Gestwicki, Jason E.
Publicado 2021

Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells

por Hong, Seung-Keun, Starenki, Dmytro, Johnson, Oleta T., Gestwicki, Jason E., Park, Jong-In
Publicado 2022

Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly

por Braxton, Julian R., Shao, Hao, Tse, Eric, Gestwicki, Jason E., Southworth, Daniel R.
Publicado 2023

An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition of Wild-Type and Drug-Resistant Proteases

por Ung, Peter M.-U., Dunbar, James B., Gestwicki, Jason E., Carlson, Heather A.
Publicado 2014

Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities

por Johnson, Oleta T., Nadel, Cory M., Carroll, Emma C., Arhar, Taylor, Gestwicki, Jason E.
Publicado 2022

Protocol for performing and optimizing differential scanning fluorimetry experiments

por Wu, Taiasean, Hornsby, Michael, Zhu, Lawrence, Yu, Joshua C., Shokat, Kevan M., Gestwicki, Jason E.
Publicado 2023

Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK

por Ung, Peter Man-Un, Thompson, Andrea D., Chang, Lyra, Gestwicki, Jason E., Carlson, Heather A.
Publicado 2013

Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

por Wu, Pui-Kei, Hong, Seung-Keun, Starenki, Dmytro, Oshima, Kiyoko, Shao, Hao, Gestwicki, Jason E., Tsai, Susan, Park, Jong-In
Publicado 2020

Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States

por Montgomery, Kelly M., Carroll, Emma C., Thwin, Aye C., Quddus, Athena Y., Hodges, Paige, Southworth, Daniel R., Gestwicki, Jason E.
Publicado 2023

De novo designed Hsp70 activator dissolves intracellular condensates

por Zhang, Jason Z, Greenwood, Nathan, Hernandez, Jason, Cuperus, Josh T, Huang, Buwei, Ryder, Bryan D, Queitsch, Christine, Gestwicki, Jason E, Baker, David
Publicado 2023

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

por Tao, Jiahui, Berthet, Amandine, Citron, Y. Rose, Tsiolaki, Paraskevi L., Stanley, Robert, Gestwicki, Jason E., Agard, David A., McConlogue, Lisa
Publicado 2021

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

por Freilich, Rebecca, Betegon, Miguel, Tse, Eric, Mok, Sue-Ann, Julien, Olivier, Agard, David A., Southworth, Daniel R., Takeuchi, Koh, Gestwicki, Jason E.
Publicado 2018

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators

por Opoku-Nsiah, Kwadwo A., de la Pena, Andres H., Williams, Sarah K., Chopra, Nikita, Sali, Andrej, Lander, Gabriel C., Gestwicki, Jason E.
Publicado 2022

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate

por Carrettiero, Daniel C., Almeida, Maria C., Longhini, Andrew P., Rauch, Jennifer N., Han, Dasol, Zhang, Xuemei, Najafi, Saeed, Gestwicki, Jason E., Kosik, Kenneth S.
Publicado 2022

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

por Nadel, Cory M., Wucherer, Kristin, Oehler, Abby, Thwin, Aye C., Basu, Koli, Callahan, Matthew D., Southworth, Daniel R., Mordes, Daniel A., Craik, Charles S., Gestwicki, Jason E.
Publicado 2023

Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

por Xu, Pengfei, Yang, Joy C., Ning, Shu, Chen, Bo, Nip, Christopher, Wei, Qiang, Liu, Liangren, Johnson, Oleta T., Gao, Allen C., Gestwicki, Jason E., Evans, Christopher P., Liu, Chengfei
Publicado 2023

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

por Molnar, Kathleen S., Dunyak, Bryan M., Su, Bonnie, Izrayelit, Yevgeniy, McGlasson-Naumann, Brittney, Hamilton, Paul D., Qian, Mingxing, Covey, Douglas F., Gestwicki, Jason E., Makley, Leah N., Andley, Usha P.
Publicado 2019

Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

por Koren, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, John C., Nguyen, Lana, Guo, Jianping, Blair, Laura J., Li, Xiokai, Jinwal, Umesh K., Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Publicado 2012