Catching a DUB in the act: novel ubiquitin-based active site directed probes

por Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Publicado 2014

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

por Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Publicado 2012

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput

por Jia, Yuqing, Kim, Robbert Q., Kooij, Raymond, Ovaa, Huib, Sapmaz, Aysegul, Geurink, Paul P.
Publicado 2022

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

por Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Publicado 2016

Profiling DUBs and Ubl-specific proteases with activity-based probes

por Geurink, Paul P., van der Heden van Noort, Gerbrand J., Mulder, Monique P.C., Knaap, Robert C.M., Kikkert, Marjolein, Ovaa, Huib
Publicado 2019

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

por Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Publicado 2015

Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry

por Brunner, Andrea M., Lössl, Philip, Geurink, Paul P., Ovaa, Huib, Albanese, P., Altelaar, A.F. Maarten, Heck, Albert J.R., Scheltema, Richard A.
Publicado 2021

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

por Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Publicado 2016

Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing

por Szczesna, Magdalena, Huang, Yizhou, Lacoursiere, Rachel E., Bonini, Francesca, Pol, Vito, Koc, Fulya, Ward, Beatrice, Geurink, Paul P., Pruneda, Jonathan N., Thurston, Teresa L.M.
Publicado 2023

Structural basis of the specificity of USP18 toward ISG15

por Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Publicado 2017

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

por Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P.
Publicado 2020

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System

por Janssen, Guido V., Zhang, Susan, Merkx, Remco, Schiesswohl, Christa, Chatterjee, Champak, Darwin, K. Heran, Geurink, Paul P., van der Heden van Noort, Gerbrand J., Ovaa, Huib
Publicado 2021

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

por Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Publicado 2013

Identification and characterization of diverse OTU deubiquitinases in bacteria

por Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Publicado 2020

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

por van der Gracht, Daniël, Rowland, Rhianna J., Roig-Zamboni, Véronique, Ferraz, Maria J., Louwerse, Max, Geurink, Paul P., Aerts, Johannes M. F. G., Sulzenbacher, Gerlind, Davies, Gideon J., Overkleeft, Herman S., Artola, Marta
Publicado 2023

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

por Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Publicado 2019

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

por Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

por Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Publicado 2016

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

por Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Publicado 2018

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

por Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Publicado 2016