Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent

por Serpi, Michaela, Ferrari, Valentina, McGuigan, Christopher, Ghazaly, Essam, Pepper, Chris
Publicado 2022

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

por Walsh, Christopher, Bonner, Jennifer J., Johnson, Trevor N., Neuhoff, Sibylle, Ghazaly, Essam A., Gribben, John G., Boddy, Alan V., Veal, Gareth J.
Publicado 2016

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

por Moniz, Larissa S., Surinova, Silvia, Ghazaly, Essam, Velasco, Lorena Gonzalez, Haider, Syed, Rodríguez-Prados, Juan Carlos, Berenjeno, Inma M., Chelala, Claude, Vanhaesebroeck, Bart
Publicado 2017

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1

por Locke, Matthew, Ghazaly, Essam, Freitas, Marta O., Mitsinga, Mikaella, Lattanzio, Laura, Lo Nigro, Cristiana, Nagano, Ai, Wang, Jun, Chelala, Claude, Szlosarek, Peter, Martin, Sarah A.
Publicado 2016

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

por Blagden, Sarah P., Rizzuto, Ivana, Suppiah, Puvan, O’Shea, Daniel, Patel, Markand, Spiers, Laura, Sukumaran, Ajithkumar, Bharwani, Nishat, Rockall, Andrea, Gabra, Hani, El-Bahrawy, Mona, Wasan, Harpreet, Leonard, Robert, Habib, Nagy, Ghazaly, Essam
Publicado 2018

Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function

por Ghazaly, Essam A., Miraki-Moud, Farideh, Smith, Paul, Gnanaranjan, Chathunissa, Koniali, Lola, Oke, Adedayo, Saied, Marwa H., Petty, Robert, Matthews, Janet, Stronge, Randal, Joel, Simon P., Young, Bryan D., Gribben, John, Taussig, David C.
Publicado 2020

Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma

por Phillips, Melissa M., Pavlyk, Iuliia, Allen, Michael, Ghazaly, Essam, Cutts, Rosalind, Carpentier, Josephine, Berry, Joe Scott, Nattress, Callum, Feng, Shenghui, Hallden, Gunnel, Chelala, Claude, Bomalaski, John, Steele, Jeremy, Sheaff, Michael, Balkwill, Frances, Szlosarek, Peter W.
Publicado 2023

A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma

por Phillips, Melissa M., Pavlyk, Iuliia, Allen, Michael, Ghazaly, Essam, Cutts, Rosalind, Carpentier, Josephine, Berry, Joe Scott, Nattress, Callum, Feng, Shenghui, Hallden, Gunnel, Chelala, Claude, Bomalaski, John, Steele, Jeremy, Sheaff, Michael, Balkwill, Frances, Szlosarek, Peter W.
Publicado 2023

Clofarabine, high-dose cytarabine and liposomal daunorubicin in pediatric relapsed/refractory acute myeloid leukemia: a phase IB study

por van Eijkelenburg, Natasha K.A., Rasche, Mareike, Ghazaly, Essam, Dworzak, Michael N., Klingebiel, Thomas, Rossig, Claudia, Leverger, Guy, Stary, Jan, De Bont, Eveline S.J.M., Chitu, Dana A., Bertrand, Yves, Brethon, Benoit, Strahm, Brigitte, van der Sluis, Inge M., Kaspers, Gertjan J.L., Reinhardt, Dirk, Zwaan, C. Michel
Publicado 2018

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

por Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
Publicado 2017