Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

por Abdelsamed, Hossam A., Moustaki, Ardiana, Fan, Yiping, Dogra, Pranay, Ghoneim, Hazem E., Zebley, Caitlin C., Triplett, Brandon M., Sekaly, Rafick-Pierre, Youngblood, Ben
Publicado 2017

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation

por Zebley, Caitlin C., Abdelsamed, Hossam A., Ghoneim, Hazem E., Alli, Shanta, Brown, Charmaine, Haydar, Dalia, Mi, Tian, Harris, Tarsha, McGargill, Maureen A., Krenciute, Giedre, Youngblood, Ben
Publicado 2021

Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

por Chen, Heng-Yi, Almonte-Loya, Ana, Lay, Fang-Yun, Hsu, Michael, Johnson, Eric, González-Avalos, Edahí, Yin, Jieyun, Bruno, Richard S, Ma, Qin, Ghoneim, Hazem E, Wozniak, Daniel J, Harrison, Fiona E, Lio, Chan-Wang Jerry
Publicado 2022

EFFECTOR CD8 T CELLS DEDIFFERENTIATE INTO LONG-LIVED MEMORY CELLS

por Youngblood, Ben, Hale, J. Scott, Kissick, Haydn T., Ahn, Eunseon, Xu, Xiaojin, Wieland, Andreas, Araki, Koichi, West, Erin E., Ghoneim, Hazem E., Fan, Yiping, Dogra, Pranay, Davis, Carl W., Konieczny, Bogumila T., Antia, Rustom, Cheng, Xiaodong, Ahmed, Rafi
Publicado 2017

Developmental plasticity allows outside-in immune responses by resident memory T cells

por Fonseca, Raissa, Beura, Lalit K, Quarnstrom, Clare F, Ghoneim, Hazem E, Fan, Yiping, Zebley, Caitlin C, Scott, Milcah C, Fares-Frederickson, Nancy J, Wijeyesinghe, Sathi, Thompson, Emily A, da Silva, Henrique Borges, Vezys, Vaiva, Youngblood, Benjamin, Masopust, David
Publicado 2020

Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity

por Read, Kaitlin A., Jones, Devin M., Pokhrel, Srijana, Hales, Emily D. S., Varkey, Aditi, Tuazon, Jasmine A., Eisele, Caprice D., Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R., Warren, Robert T., Powell, Michael D., Boss, Jeremy M., Hemann, Emily A., Yount, Jacob S., Xin, Gang, Ghoneim, Hazem E., Lio, Chan-Wang J., Freud, Aharon G., Collins, Patrick L., Oestreich, Kenneth J.
Publicado 2023

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of Me...

por Daily, Kylene P., Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H., Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A., Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A., Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N., Ghoneim, Hazem E., Amer, Amal O.
Publicado 2023

Beta cell-specific CD8(+) T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes

por Abdelsamed, Hossam A., Zebley, Caitlin C., Nguyen, Hai, Rutishauser, Rachel L., Fan, Yiping, Ghoneim, Hazem E., Crawford, Jeremy Chase, Alfei, Francesca, Alli, Shanta, Ribeiro, Susan Pereira, Castellaw, Ashley H., McGargill, Maureen A., Jin, Hongjian, Boi, Shannon K., Speake, Cate, Serti, Elisavet, Turka, Laurence A., Busch, Michael E., Stone, Mars, Deeks, Steven G., Sekaly, Rafick-Pierre, Zehn, Dietmar, James, Eddie A., Nepom, Gerald T., Youngblood, Ben
Publicado 2020