Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

por Gianquinto, Eleonora, Tondi, Donatella, D’Arrigo, Giulia, Lazzarato, Loretta, Spyrakis, Francesca
Publicado 2020

Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction

por D’Arrigo, Giulia, Gianquinto, Eleonora, Rossetti, Giulia, Cruciani, Gabriele, Lorenzetti, Stefano, Spyrakis, Francesca
Publicado 2021

Exploring Ligand Binding Domain Dynamics in the NRs Superfamily

por D’Arrigo, Giulia, Autiero, Ida, Gianquinto, Eleonora, Siragusa, Lydia, Baroni, Massimo, Cruciani, Gabriele, Spyrakis, Francesca
Publicado 2022

Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development

por Marchetti, Marialaura, De Bei, Omar, Bettati, Stefano, Campanini, Barbara, Kovachka, Sandra, Gianquinto, Eleonora, Spyrakis, Francesca, Ronda, Luca
Publicado 2020

N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Rece...

por Gianquinto, Eleonora, Sodano, Federica, Rolando, Barbara, Kostrzewa, Magdalena, Allarà, Marco, Mahmoud, Ali Mokhtar, Kumar, Poulami, Spyrakis, Francesca, Ligresti, Alessia, Chegaev, Konstantin
Publicado 2022

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases

por Linciano, Pasquale, Gianquinto, Eleonora, Montanari, Martina, Maso, Lorenzo, Bellio, Pierangelo, Cebrián-Sastre, Esmeralda, Celenza, Giuseppe, Blázquez, Jesús, Cendron, Laura, Spyrakis, Francesca, Tondi, Donatella
Publicado 2020

Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight

por Gianquinto, Eleonora, Moscetti, Ilaria, De Bei, Omar, Campanini, Barbara, Marchetti, Marialaura, Luque, F. Javier, Cannistraro, Salvatore, Ronda, Luca, Bizzarri, Anna Rita, Spyrakis, Francesca, Bettati, Stefano
Publicado 2019

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor

por Gastaldi, Simone, Boscaro, Valentina, Gianquinto, Eleonora, Sandall, Christina F., Giorgis, Marta, Marini, Elisabetta, Blua, Federica, Gallicchio, Margherita, Spyrakis, Francesca, MacDonald, Justin A., Bertinaria, Massimo
Publicado 2021

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

por Santucci, Matteo, Luciani, Rosaria, Gianquinto, Eleonora, Pozzi, Cecilia, Pisa, Flavio di, dello Iacono, Lucia, Landi, Giacomo, Tagliazucchi, Lorenzo, Mangani, Stefano, Spyrakis, Francesca, Costi, Maria Paola
Publicado 2021

Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction

por De Bei, Omar, Marchetti, Marialaura, Ronda, Luca, Gianquinto, Eleonora, Lazzarato, Loretta, Chirgadze, Dimitri Y., Hardwick, Steven W., Cooper, Lee R., Spyrakis, Francesca, Luisi, Ben F., Campanini, Barbara, Bettati, Stefano
Publicado 2022

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

por Spyrakis, Francesca, Santucci, Matteo, Maso, Lorenzo, Cross, Simon, Gianquinto, Eleonora, Sannio, Filomena, Verdirosa, Federica, De Luca, Filomena, Docquier, Jean-Denis, Cendron, Laura, Tondi, Donatella, Venturelli, Alberto, Cruciani, Gabriele, Costi, Maria Paola
Publicado 2020

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF(V600E) Protein

por Marini, Elisabetta, Marino, Marco, Gionfriddo, Giulia, Maione, Federica, Pandini, Marta, Oddo, Daniele, Giorgis, Marta, Rolando, Barbara, Blua, Federica, Gastaldi, Simone, Marchiò, Serena, Kovachka, Sandra, Spyrakis, Francesca, Gianquinto, Eleonora, Di Nicolantonio, Federica, Bertinaria, Massimo
Publicado 2022