Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

por Uchihara, Toshiki, Giasson, Benoit I.
Publicado 2015

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

por Sacino, Amanda N, Giasson, Benoit I
Publicado 2012

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

por Xia, Yuxing, Prokop, Stefan, Giasson, Benoit I.
Publicado 2021

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation

por Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Publicado 2023

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

por Rutherford, Nicola J., Brooks, Mieu, Giasson, Benoit I.
Publicado 2016

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

por Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Publicado 2021

Targeted proteolytic products of τ and α-synuclein in neurodegeneration

por Xia, Yuxing, Lloyd, Grace M., Giasson, Benoit I.
Publicado 2021

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation

por Xia, Yuxing, Bell, Brach M., Kim, Justin D., Giasson, Benoit I.
Publicado 2023

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy

por Williams, Tosha, Sorrentino, Zachary, Weinrich, Mary, Giasson, Benoit I, Chakrabarty, Paramita
Publicado 2020

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

por Koller, Emily J., Brooks, Mieu M. T., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Publicado 2017

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome

por Park, Hyo-Jin, Ryu, Daniel, Parmar, Mayur, Giasson, Benoit I., McFarland, Nikolaus R.
Publicado 2017

Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology

por Paterno, Giavanna, Bell, Brach M., Gorion, Kimberly-Marie M., Prokop, Stefan, Giasson, Benoit I.
Publicado 2022

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

por Smith, Ethan D., Vo, Quan, Giasson, Benoit I., Borchelt, David R., Prokop, Stefan, Chakrabarty, Paramita
Publicado 2023

Designing antibodies against LRRK2-targeted tau epitopes

por Hamm, Matthew, Ladd, Thomas B., Levites, Yona, Golde, Todd E., Giasson, Benoit I., Lewis, Jada
Publicado 2018

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

por Pace, Michael C., Xu, Guilian, Fromholt, Susan, Howard, John, Giasson, Benoit I., Lewis, Jada, Borchelt, David R.
Publicado 2018

Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons

por Wilson, Christina A., Murphy, Diane D., Giasson, Benoit I., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2004

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies

por Dhillon, Jess-Karan S., Riffe, Cara, Moore, Brenda D., Ran, Yong, Chakrabarty, Paramita, Golde, Todd E., Giasson, Benoit I.
Publicado 2017

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau

por Croft, Cara L., Moore, Brenda D., Ran, Yong, Chakrabarty, Paramita, Levites, Yona, Golde, Todd E., Giasson, Benoit I.
Publicado 2018

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

por Hass, Ethan W., Sorrentino, Zachary A., Lloyd, Grace M., McFarland, Nikolaus R., Prokop, Stefan, Giasson, Benoit I.
Publicado 2021

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

por Sorrentino, Zachary A., Brooks, Mieu M.T., Hudson, Vincent, Rutherford, Nicola J., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Publicado 2017