Benchmark Calculations for Perchlorate from Three Human Cohorts

por Crump, Kenny S., Gibbs, John P.
Publicado 2005

Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development

por Gibbs, John P., Menon, Rajeev, Kasichayanula, Sreeneeranj
Publicado 2017

The NAS Perchlorate Review: Second-Guessing the Experts

por Gibbs, John P., Engel, Arnold, Lamm, Steven H.
Publicado 2005

Quantitative Assessment of Elagolix Enzyme-Transporter Interplay and Drug–Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

por Chiney, Manoj S., Ng, Juki, Gibbs, John P., Shebley, Mohamad
Publicado 2019

Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology

por Weddell, Jared, Chiney, Manoj S., Bhatnagar, Sumit, Gibbs, John P., Shebley, Mohamad
Publicado 2020

Characterization of a quantitative method to measure free proprotein convertase subtilisin/kexin type 9 in human serum

por Colbert, Alexander, Umble-Romero, Amber, Prokop, Samantha, Xu, Ren, Gibbs, John P, Pederson, Susan
Publicado 2014

Accelerating Drug Development in Pediatric Oncology With the Clinical Pharmacology Storehouse

por Shebley, Mohamad, Menon, Rajeev M., Gibbs, John P., Dave, Nimita, Kim, Su Y., Marroum, Patrick J.
Publicado 2018

Population pharmacokinetics and exposure–response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia

por Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P., Doshi, Sameer
Publicado 2018

Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions

por Clements, John David, Perez Ruixo, Juan Jose, Gibbs, John P., Doshi, Sameer, Perez Ruixo, Carlos, Melhem, Murad
Publicado 2018

Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor

por Kasichayanula, Sreeneeranj, Grover, Anita, Emery, Maurice G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P.
Publicado 2018

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteo...

por Gow, Jason M., Tsuji, Wayne H., Williams, Gary J., Mytych, Daniel, Sciberras, David, Searle, Shawn L., Mant, Tim, Gibbs, John P.
Publicado 2015

Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety

por Lee, Edward, Gibbs, John P., Emery, Maurice G., Block, Geoffrey, Wasserman, Scott M., Hamilton, Lisa, Kasichayanula, Sreeneeranj, Hanafin, Patrick, Somaratne, Ransi, Egbuna, Ogo
Publicado 2019

Evaluation of Evolocumab (AMG 145), a Fully Human Anti‐PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment

por Gibbs, John P., Slatter, J. Greg, Egbuna, Ogo, Geller, Michelle, Hamilton, Lisa, Dias, Clapton S., Xu, Ren Y., Johnson, Jessica, Wasserman, Scott M., Emery, Maurice G.
Publicado 2016

Impact of Target‐Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

por Gibbs, John P., Doshi, Sameer, Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Dodds, Michael G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Blom, Dirk
Publicado 2016

Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

por Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., van der Graaf, Piet H., Kierzek, Andrzej M.
Publicado 2020